Nicotine-free Hookah Smoking
Conditions
Keywords
Nicotine-free hookah, Waterpipe, Smoking, Sympathetic
Brief summary
This is a pilot study on the acute effects of nicotine-free hookah (herbal/steam stones) smoking on the sympathetic neural control of the human cardiovascular system. Hookah smoking is known to transiently increase blood pressure and heart rate while decreasing heart rate variability suggesting - but not proving - sympathetic mediation. The contribution of nicotine to these effects is unknown. Here the investigators will directly measure the acute effects of nicotine-free Hookah smoking on sympathetic nerve activity with microneurography (intraneural microelectrodes) and quantify associated regional changes in vasomotor tone.
Interventions
OTHERNicotine free hookah smoking
Subjects will smoke waterpipe in a controlled research environment
Sponsors
Cedars-Sinai Medical Center
Study design
Allocation
NA
Intervention model
SINGLE_GROUP
Primary purpose
OTHER
Masking
NONE
Eligibility
Sex/Gender
ALL
Age
18 Years to 39 Years
Healthy volunteers
Yes
Inclusion criteria
* 18 to 39 years of age * Habitual Hookah smoker defined as having smoked Hookah \>=12 times in the past 12 months * Have not smoked cigarettes within the past 12 months
Exclusion criteria
* Exhaled carbon monoxide level greater than 10 ppm\* as evidence of current or recent cigarette (excluded if smoked cigarette within 12 months) or Hookah smoking (excluded if smoked Hookah within past 72 hours) * History of cardiopulmonary disease * Use of any prescription medication with exception of oral contraceptive pills * History of psychiatric illness * History of neurologic disease * BMI ≥ 35 * Evidence of any of the above by physical examination, ECG or echocardiogram * Smoked cigarette in the past 12 months * History of illicit drug use * Pregnant * Any other condition(s) deemed by the physician investigators that put subjects at risk for participating in the study
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Change in sympathetic nerve activity | Change from baseline in sympathetic nerve activity at 1 hr | Multi-unit recordings of sympathetic nerve activity will be obtained with single-use sterile tungsten microelectrodes inserted selectively into muscle or skin nerve fascicles of the peritoneal nerve. |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Change in regional myocardial perfusion | Change from baseline in regional myocardial perfusion at 1 hr | Myocardial contrast echocardiography will be used to measure regional myocardial perfusion (i.e. capillary blood volume) and coronary flow reserve. |
Other
| Measure | Time frame | Description |
|---|---|---|
| Change in leg blood flow | Change from baseline in leg blood flow at 1 hr | Lower leg blood flow will be measured with standard venous occlusion plethysmography. |
Countries
United States
Outcome results
None listed