Intermittent Claudication
Conditions
Keywords
Mitochondria, muscle, Exercise, Blood Flow Velocity
Brief summary
The aim of the study is to evaluate whether walking capacity in patients with intermittent claudication is improved more by home-based 5+ exercise training than by current recommendations of daily walking. The study will elucidate if such a potential effect is dependent on changes in mitochondrial respiratory capacity, blood flow or both.
Interventions
OTHERFive plus exercise training
calf raise exercise
Sponsors
Norwegian University of Science and Technology
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT
Masking
SINGLE (Outcomes Assessor)
Eligibility
Sex/Gender
ALL
Age
50 Years to 80 Years
Healthy volunteers
No
Inclusion criteria
* Diagnosed with intermittent claudication secondary to vascular insufficiency * An ankle-brachial index between 0.4 and 0.9.
Exclusion criteria
* Diagnosed with critical limb ischemia * Ankle-brachial index (ABI) \> 0.90 or \< 0.4 * Limited exercise tolerance * Warfarin or heparin usage * Underwent a vascular intervention in the last 6 months * Active cancer, renal- or liver disease
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| absolute walking distance (meters) as measured by 6 minute walking test | 8 weeks | treadmill 3.2 km/hour and inclination increase every 2 minute combined with 6 minute walking test |
| mitochondrial function measured by respirometry | 8 weeks | Oxygen consumption (pmol O2 per second per mg of wet weight tissue) measured by respirometry |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Arterial bloodflow measured by plethysmography | 8 weeks | measured by plethysmography |
| Quality of life assessed by SF 36 and CLAU-S questionnaires | 8 weeks | assessed by SF 36 and CLAU-S questionnaires |
| Peak oxygen uptake measured by cardio-pulmonal exercise testing | 8 weeks | measured by cardio-pulmonal exercise testing |
Countries
Norway
Outcome results
None listed