Validation of New Tools for the Assessment of Cognitive Functions and Connectivity Network in Hypertensive Patients

Status

Completed

Phases

Unknown

Study type

Observational

Source

ClinicalTrials.gov

Registry ID

NCT02310217

Enrollment

160

Registered

2014-12-08

Start date

2015-02-28

Completion date

2020-12-31

Last updated

2022-04-20

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Cognitive Impairment, Hypertension

Keywords

Hypertension, Cognitive impairment, Biomarkers

Brief summary

The relationship among hypertension, aging and cognitive decline is complex and not completely understood. Purpose of this project will be evaluating early markers of cognitive deterioration in patients with arterial hypertension. In particular, this cross-sectional observational study will be articulated in three phases: 1. Neuropsychological evaluation of general cognitive abilities 2. Identification and measurement of specific biomarker levels 3. Correlation among hypertension, cognitive abilities and biomarkers.

Interventions

None listed

Study design

Observational model

OTHER

Time perspective

CROSS_SECTIONAL

Eligibility

Sex/Gender

ALL

Age

40 Years to 65 Years

Healthy volunteers

Inclusion criteria

* Males or females diagnosed with arterial hypertension between 40 and 65 years of age; * Written informed consent prior to enrollment in the study.

Exclusion criteria

* Precedent acute myocardial infarction (AMI); * Previous stroke and/or transient ischemic attack (TIA); * Previous or concomitant neurologic or psychiatric pathologies; * Neurologic or psychiatric pharmacological therapy.

Design outcomes

Primary

Measure	Time frame
Cognitive abilities measured by validated neuropsychological test battery (Montreal Cognitive Assessment test, Verbal Fluency test,learning of couple words, Stroop test)	18 months

Countries

Italy

Outcome results