Deficit in Manual Activities, Stroke
Conditions
Keywords
bi-manual , motor skill learning , stroke , chronic patients,neuro-rehabilitative robot
Brief summary
Noninvasive brain stimulations (NIBS) will be used in healthy volunteers and in chronic stroke patients to improve bimanual activities and motor learning. Functional magnetic resonance imaging will be used to evaluate the mechanisms underlying bimanual activities and motor learning in healthy volunteers and in chronic stroke patients. A neuro-rehabilitation robot (REA2PLAN, AXINESIS, Louvain-la-Neuve, Belgium) will be used for motor learning.
Detailed description
tDCS will be used in a sham-controlled, double-blind, randomized, cross-over control trial in chronic stroke patients with motor deficits. After informed consent and recruitment, patients will be randomly (computer method) allocated to real or sham tDCS, that will be applied during performance of bimanual activities and/or motor learning. A few minutes/hours/days/weeks after completing one trial's arm, the patients will enter the other trial's arm (double-blind cross-over design). Baseline and follow-up outcomes about bimanual and unimanual motor tasks will be collected. For a subset of subjects, motor learning and data acquisition will be performed with a neuro-rehabilitation robot (REA2PLAN, AXINESIS, Louvain-la-Neuve, Belgium) .
Interventions
DEVICEtDCS
Sponsors
University Hospital of Mont-Godinne
Study design
Allocation
RANDOMIZED
Intervention model
CROSSOVER
Primary purpose
TREATMENT
Masking
QUADRUPLE (Subject, Caregiver, Investigator, Outcomes Assessor)
Intervention model description
tDCS real versus sham tDCS (this is what this is)
Eligibility
Sex/Gender
ALL
Age
18 Years to 95 Years
Healthy volunteers
Yes
Inclusion criteria
• stroke with at least slight deficit
Exclusion criteria
* epilepsy * contraindication to tDCS and/or to fMRI * presence of metal in the head * inability to understand / complete behavioral tasks * chronic intake of alcohol or recreational drugs * major health condition * presence of pacemaker (for the fMRI part only) * pregnancy
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| bimanual coordination | up to 2 hours after intervention. Recall test at 1 week and up to,2,3,4 weeks after the intervention | The effect of intervention on bimanual motor coordination will be quantified before, during and after executive tasks. |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| standard unimanual evaluation | immediately, 30, 60 min; and up to 2 hours after intervention. Recall test at 1 week and up to,2,3,4 weeks after the intervention) | Performance on motor skill learning tasks and on different commonly used tasks (Purdue Pegboard, hand dynamometer, pinch dynamometer, 9-HPT, motor skill learning with a videogame, ...) will be measured to explore the impact of tDCS on these parameters in chronic stroke patients. |
Countries
Belgium
Outcome results
None listed