Azoospermia, Oligospermia
Conditions
Keywords
infertility
Brief summary
The purpose of this study is to determine whether uFSH is effective and safe in the treatment of male patients with severe oligospermia or azoospermia.
Interventions
DRUG75IU uFSH
Sponsors
Livzon Pharmaceutical Group Inc.
Study design
Allocation
RANDOMIZED
Intervention model
SINGLE_GROUP
Primary purpose
TREATMENT
Masking
NONE
Eligibility
Sex/Gender
MALE
Age
25 Years to 35 Years
Healthy volunteers
No
Inclusion criteria
* Male subjects aged 20\ 35. * They accorded with diagnostic criteria of severe oligospermia or azoospermia. * They had'nt been treated with drug which could improve sperm count and quality one month before observation，otherwise,they should have a elution for 1 month before the study.
Exclusion criteria
* Gram-positive bacteria ,Chlamydia trachomatis,Ureaplasmaurealyticum,or mycoplasma hominis were detected in their semen. * Subjects addicted to drug，tobacco，or alcohol. * Subjects had heat,chemicals,radioactive material,or toxic contact history within a year. * Subjects were under treatment of gonadotropin,anabolic steroid,chemotherapeutic drugs,or nonsteroidal anti-inflammatory drugs . * Subjects combined with cardiovascular, liver, kidney ,or hematopoietic system severe primary disease,or mental disease. * Subjects were allergic or on uFSH allergy,or under the treatment of other drugs for infertility . * Subjects did not meet the inclusion criteria, did not according to the prescribed medication, were unable to judge the efficacy ,had incomplete information, or affected the efficacy or safety judgment. * Subjects were IHH patients
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Sperm density | 6 month |
| (A + B)grade sperm and sperm activity rate | 6 month |
| A grade sperm | 6 month |
| semen volume | 6 month |
| sex hormone levels | 6 month |
| testis volume | 6 month |
Countries
China
Outcome results
None listed