Ocular Surface Dry Eye Microbiome

Microbiome Analysis of the Ocular Surface in Dry Eye Disease

Status

UNKNOWN

Phases

Unknown

Study type

Observational

Source

ClinicalTrials.gov

Registry ID

NCT02306668

Enrollment

Registered

2014-12-03

Start date

2014-02-28

Completion date

2016-12-31

Last updated

2014-12-03

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Dry Eyes

Keywords

Dry eye

Brief summary

The investigators seek to characterize the identity of all microorganisms residing on the eye's surface (conjunctiva) in healthy eyes and those with dry eye syndrome, using a combination of analyses. Dry eye disease is thought to have an inflammatory basis and in the vast majority of cases the cause of the chronic inflammatory condition is unknown.

Interventions

None listed

Study design

Observational model

CASE_CONTROL

Time perspective

PROSPECTIVE

Eligibility

Sex/Gender

ALL

Age

18 Years to No maximum

Healthy volunteers

Yes

Inclusion criteria

* dry eye syndrome with OSDI score greater than 60 * control group with OSDI score less than 30

Exclusion criteria

* recent history of contact lens wear * use of topical antibiotics or prescription eye medication in past 6 months * penetrating ocular surgery in the last 12 months * age less than 18 years

Design outcomes

Primary

Measure	Time frame
Identification of bacteria or fungus from conjunctival swab	1 month

Countries

United States

Contacts

Primary ContactSue Rath, COT

raths@uw.edu206-897-4331

Outcome results