Intraocular Pressure Changes After Glucosamine Sulfate Consumption.
Conditions
Brief summary
In this double blind clinical trial 92 patients suffering from rheumatoid arthritis are included. Those with the history of intraocular and corneal surgery, diabetic and heavy smokers are excluded from the study. Before starting the treatment all patients undergo complete ophthalmic exam, corneal biomechanical properties assessment by Ocular Response Analyzer (ORA) and corneal thickness measurement. Patients are randomly assigned to treatment and placebo groups. Those in the treatment groups receive glucosamine sulfate 1500 mg three times a day. Those in placebo arm receive alike capsule with the same schedule. At month 3 and 6 IOP(intraocular pressure), ORA and pachymetry would be checked again.
Interventions
DRUGPlacebo three times a day
DRUGglucosamine sulfate 1500 mg three times a day
Sponsors
Shahid Beheshti University of Medical Sciences
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
PREVENTION
Masking
DOUBLE (Subject, Caregiver)
Eligibility
Sex/Gender
ALL
Age
40 Years to No maximum
Healthy volunteers
Yes
Inclusion criteria
* History of rheumatoid arthritis based on ACR (American College of Rheumatology)FC(functional classes). * No history of using drugs tested in the study.
Exclusion criteria
* History of any kind of corneal surgery. * History of intraocular surgery. * History of diabetes mellitus. * Heavy smokers. * Unwillingness to participate in the study.
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Intraocular pressure changes | until 6 months | : Goldmann applanation tonometry |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| corneal biomechanical changes | until 6 months | Ocular Response Analyzer (ORA) |
Countries
Iran
Contacts
Primary ContactMohammad Pakravan, MD
Outcome results
None listed