Thrombocytopenia
Conditions
Keywords
Bleeding, Platelet indices, Platelet aggregometry, Bleeding questionnaire
Brief summary
The purpose of the study is to investigate whether platelet indices from automated haematology equipment, whole blood impedance aggregometry and a standardized bleeding questionnaire predict bleeding in admitted patients with thrombocytopenia of various causes.
Detailed description
Thrombocytopenia is a risk factor for bleeding, but studies concerning markers for stratification of bleeding risk among thrombocytopenic patients are lacking. This prospective observational cohort study investigates risk factor for bleeding in admitted patients with thrombocytopenia of various causes.
Interventions
None listed
Sponsors
Pernille Just Vinholt
Study design
Observational model
COHORT
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Healthy volunteers
No
Inclusion criteria
* Admitted patients with thrombocytopenia * Age ≥18 years * Platelet count below 80 x109/L
Exclusion criteria
* Platelet transfusion within the previous 14 days, * surgery or trauma within the previous 7 days * Unable to give informed consent.
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Mean platelet volume | 30 days | Mean platelet volume (femtolitre (fL)) |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Bleeding questionnaire | 30 days | Bleeding score based on the condensed MCMDM-1 VWD bleeding questionnaire |
| Platelet count | 30 days | Platelet count ( x10'9/L) |
| immature platelet fraction | 30 days | immature platelet fraction (%) |
| Platelet aggregation | 30 days | Platelet aggregation by Multiplate Analyzer (aggregation units\* min) |
Outcome results
None listed