Squamous Cell Carcinoma of Glottis
Conditions
Keywords
CO2 laser surgery, open surgery, multicenter prospective, randomized, controlled clinical studies, T1N0 squamous cell carcinoma of glottis with anterior commissure involved
Brief summary
Open surgery and CO2 laser surgery are both established treatment modalities for T1N0 glottic carcinoma. It is controversial for T1N0 glottic carcinoma with anterior commissure involved.
Interventions
PROCEDURECO2 Laser surgery
Patients were randomly assigned to CO2 laser surgery group and open Surgery group.
PROCEDUREOpen Surgery
Patients were randomly assigned to CO2 laser surgery group and open Surgery group.
Sponsors
First Affiliated Hospital, Sun Yat-Sen University
Sun Yat-Sen Memorial Hospital of Sun Yat-Sen University
Third Affiliated Hospital, Sun Yat-Sen University
Xuekui Liu
Study design
Allocation
RANDOMIZED
Intervention model
FACTORIAL
Primary purpose
TREATMENT
Masking
SINGLE (Investigator)
Eligibility
Sex/Gender
ALL
Age
20 Years to 70 Years
Healthy volunteers
No
Inclusion criteria
* T1N0 SCC of glottic carcinoma with anterior commissure involve * No nodal metastasis and distant metastasis * All patients must have CT/MR and electronic laryngoscope test before surgery and after surgery * Expected lifetime\>1 year * Patients and families agreed to participate in the test and sign the informed consent * Without cognitive impairment.
Exclusion criteria
* With severe cardiac insufficiency Liver and kidney function is not complete systemic infection patients * Patients with pregnancy and lactation * Have surgery contraindications
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| disease-free survival | 5 years |
Secondary
| Measure | Time frame |
|---|---|
| recurrence rate | 5 years |
Countries
China
Contacts
Primary Contactxuekui liu, doctor
Outcome results
None listed