Coronary Artery Disease
Conditions
Keywords
Training Protocol, Cardiac Rehabilitation, High-Intensity Interval Training, Continuous Training, Pyramid Training, Physical Performance
Brief summary
It is the aim of our study to compare the effects of 6 and/or 2 years of either HIT (carried out at correctly assessed 85-95% of maximal heart rate), pyramid, or continuous endurance training, on changes of physical exercise capacity in cardiac patients.
Detailed description
The three exercise arms (isocaloric) are composed as follows: Endurance training: 31 min at 65-75% HRmax, making it a total of 25min; HIT: 4x4min intervals at 85-95% HRmax divided by 3x3min of active recovery at 60-70% HRmax, making it a total of 25 min; Pyramid: One pyramid consists of 8 one-minute blocks. Those are grouped starting with one block of 70-75% HRmax, followed by one block at 75-80% HRmax and another one at 80-85% HRmax. The top of the pyramid are 2 blocks of 85-90% HRmax. Intensity is lowered afterwards with one block of 80-85% HRmax, followed by one block at 75-80% HRmax and last one at 70-75% HRmax. Two more pyramids follow, each divided by 2min of active recovery at 65-70% HRmax, making it a total of 28min. All protocols are initiated by 5min of warm-up and end with 5min of cool-down, both at 60-70% HRmax. Primary Outcome: Individual maximum power output in watt (Pmax). Secondary Outcome: Change of power output in watt at lactate tresholds at 2 and 4mmol/l.
Interventions
Endurance training with constant work load 31min at 65-75% Hrmax
OTHERPyramid Training
One pyramid consists of 8 one-minute blocks. Those are grouped starting with one block of 70-75% HRmax, followed by one block at 75-80% HRmax and another one at 80-85% HRmax. The top of the pyramid are 2 blocks of 85-90% HRmax. Intensity is lowered afterwards with one block of 80-85% HRmax, followed by one block at 75-80% HRmax and last one at 70-75% HRmax. Two more pyramids follow, each divided by 2min of active recovery at 65-70% HRmax, making it a total of 28min.
OTHERHigh-intensity interval training
HIT: 4x4 min intervals at85-95% HRmax divided by 3x3min of active recovery at 60-70% HRmax, making it a total of 25min.
Sponsors
Paracelsus Medical University
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT
Masking
NONE
Eligibility
Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
No
Inclusion criteria
* acute coronary syndrome (STEMI - NONSTEMI) * aortocoronary bypass surgery * percutaneous coronary intervention (PCI) * state after stable coronary heart disease * state after heart surgeries * state after myo-, endo-, or pericarditis * state after heart- or lung-transplantation * state after heart failure * state after pulmonary hypertension * state after peripheral venous disease * state after electrophysiological surgery * state after implantation of an implantable cardioverter or difibrillator * Patients at high risk * Patients with cardiac dysrhythmias or sudden death
Exclusion criteria
* unstable angina pectoris * Heart failure (NYHA IV) * acute myo-, endo-, or pericarditis or other infections * pulmonary-arterial embolism or phlebothrombosis within 6 months * hemodynamic instable dysrhythmias * hypertrophic cardiomyopathy * medical conditions which prevent patients from complying with the exercise program
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Physical work capacity (PWC) | 6 weeks or 36 weeks | PWC will be measured by graded exercise testing on cycle ergometer. |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Blood pressure | 6 weeks or 36 weeks | Blood pressure will be measured by graded exercise testing on cycle ergometer. |
| Lactate Thresholds | 6 weeks or 36 weeks | Lactate thresholds will be measured by graded exercise testing on cycle ergometer. |
| Metabolical and cellular blood parameter | 6 weeks or 36 weeks | Blood will be taken before and after intervention |
| Heart rate | 6 weeks or 36 weeks | Heart rate will be measured by graded exercise testing on cycle ergometer. |
| Gene expression | 6 weeks or 36 weeks | Gene expression will be taken before and after intervention |
| Quality of Life | 6 weeks or 36 weeks | Quality of Life will be taken before and after intervention |
| BMI | 6 weeks or 36 weeks | BMI will be taken before and after intervention |
Countries
Austria
Outcome results
None listed