Toxicity Attributed to Genetic Polymorphisms in Testicular Germ Cell Tumor Survivors

Status

Completed

Phases

Unknown

Study type

Observational

Source

ClinicalTrials.gov

Registry ID

NCT02303015

Enrollment

430

Registered

2014-11-27

Start date

2014-08-31

Completion date

2023-06-30

Last updated

2023-11-21

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Germ Cell Cancer

Keywords

Germ cell cancer, Late toxicity, Renal impairment, Cardiovascular disease

Brief summary

The purpose of this study is to identify genetic variations in survivors of testicular cancer and connect these variations to differences in risks of late effects.

Detailed description

Identification of late-effects through questionnaires and linkage to national registries. DNA samples will be gathered through buccal swabs or saliva kits and analysed with whole exome-sequencing.

Interventions

None listed

Study design

Observational model

COHORT

Time perspective

RETROSPECTIVE

Eligibility

Sex/Gender

MALE

Age

15 Years to No maximum

Healthy volunteers

Inclusion criteria

* Danish citizen * Diagnosed with germ cell cancer from 1984 to 2007 * Treated initially at a Danish hospital * Treated with standard treatment regimens.

Exclusion criteria

* Treated initially at a foreign hospital

Design outcomes

Primary

Measure	Time frame	Description
Renal toxicity (Identify genetic variations predicting renal toxicity)	1 year	Identify genetic variations predicting renal toxicity.

Countries

Denmark

Outcome results