Parkinson's Disease
Conditions
Keywords
MRI
Brief summary
The purpose of this study is to evaluate our recently developed MRI reconstruction strategy for producing artifact-free neuro and abdominal MRI data. The new reconstruction strategies, including 1) REKAM and 2) MUSE, are capable of effectively removing motion-related artifacts resulting from global and local motion during neuro and free-breathing abdominal MRI scans, without modifying the MRI pulse sequences and protocols that are currently used in clinical scans. The study team aims to recruit 60 subjects across multiple challenge patient populations: 10 healthy young adults (age 20-30) and 10 healthy older adults (aged 50-70) for abdominal MRI, as well as 20 tremor dominant PD patients and 20 children (age 4-8) for brain MRI scans. There are no known risks in taking MRIs and a unique code will be assigned to each participant to protect their PHI.
Interventions
DEVICEMultiplex Sensitivity Encoding (MUSE)
It is an algorithm for MRI post-processing/image reconstruction (see reference: Chen).
Sponsors
Duke University
Study design
Observational model
CASE_CONTROL
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Healthy volunteers
Yes
Inclusion criteria
1. subject's age is within one of the following age ranges (4-8, 20-30, or 50-70 years old); 2. male or female; 3. healthy volunteer or diagnosed with PD ; and 4. devoid of the following
Exclusion criteria
.
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Rating of image quality (based on 8 criteria) by multiple radiologists (blind to reconstruction method) | 1 day (At time of image analysis) | The ratings will be compared to compare the quality of images processed with MUSE versus conventional reconstruction methods |
Countries
United States
Outcome results
None listed