Surgical Infection Rates With Adjunct Vancomycin Compared to Standard Peri-Operative IV Antibiotics

Status

UNKNOWN

Phases

Study type

Interventional

Source

ClinicalTrials.gov

Registry ID

NCT02299882

Enrollment

700

Registered

2014-11-24

Start date

2012-08-31

Completion date

2016-01-31

Last updated

2014-11-24

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Lumbar Pain

Keywords

Posterior spine surgery, infection, vancomycin, surgical wound infection

Brief summary

Determine the effect of Vancomycin Powder added to the surgical wound at closure on surgical infection rates.

Detailed description

Study will be blinded and randomized 1:1 to either Vancomycin Powder at closure or no vancomycin powder at closure.

Interventions

DRUGVancomycin

Patient will be randomized to either vancomycin or no vancomycin. This treatment will take place prior to the closure of the incision from back surgery.

Study design

Allocation

RANDOMIZED

Intervention model

SINGLE_GROUP

Primary purpose

PREVENTION

Masking

SINGLE (Subject)

Eligibility

Sex/Gender

ALL

Age

18 Years to No maximum

Healthy volunteers

Inclusion criteria

* All adult, 18 years or greater undergoing posterior approach spinal surgery

Exclusion criteria

* Prisoner, pregnant women, patient under the age of 18, those of diminished decision making capacity. * patients with known reaction to Vancomycin. * patients having surgery specifically for spine infection * patients having ADCF or ALIF

Design outcomes

Primary

Measure	Time frame
Surgical wound infection rate, both deep and superficial infections	12 weeks post surgery

Secondary

Measure	Time frame
Post-operative rate of MRSA infections.	12 weeks post surgery

Countries

United States

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026