Colorectal Cancer, Surgery
Conditions
Keywords
Colorectal neoplasm, Physical activity
Brief summary
This study will compare the outcome after surgery between a group of patients that receives instructions for prehabilitation training and one group that received standard treatment.
Detailed description
The aim of this study is to investigate whether a training program with intensified physical activity prior to and after a surgical procedure reduces the surgical-related postoperative recovery time, hospital stay, sick leave and complication rate. A secondary aim is to investigate the effect of a training program with pre- and post- operative PA on the rate of resumption of QoL and normal physical function.
Interventions
OTHERPhysical activity
The intervention will take place both pre- and postoperatively. During the hospital stay both groups will be treated in the same manner.
Sponsors
Sahlgrenska University Hospital
Study design
Allocation
RANDOMIZED
Intervention model
SINGLE_GROUP
Primary purpose
PREVENTION
Masking
NONE
Eligibility
Sex/Gender
ALL
Healthy volunteers
No
Inclusion criteria
* Diagnosed colorectal cancer and a planned surgical procedure
Exclusion criteria
* HIPEC surgery, not able to give informed consent or understand the intervention
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Recovery measured as physical recovery measured in questionnaire | 4-6 weeks |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Psychological recovery measured in a questionnaire, patient reported | 4-6 weeks and 1 year post-operatively | Recovery |
| Recovery measured as time back to work | 1 year | Recovery |
| Complications according to Clavien-Dindo | within 90 days | Postoperative complications |
| QoL measured using SF-36 | 4-6 weeks and 1 year | QoL according to SF-36 |
| QoL measured using EQ-5D | 4-6 weeks and 1 year | QoL according to EQ-5D |
| QoL measured using a specifically developed instrument for this study | 4-6 weeks and 1 year | Health related QoL |
| Mortality | 3 and 5 years | Long term mortality |
| Re-admissions | 1 year | Hospital re-admissions |
| Reoperations | 1 year | Reoperations |
| Total time of hospital stay | 1 year | Length of stay |
| IGF-1 and IGFBP-3 | 4 weeks postopeartively | Lab values |
| Postoperative pain measured with Brief Pain Inventory-Short form | 4 weeks | Pain measured by BPI-S |
| Health economic analysis | 4 weeks | Health economic analysis modified according to results of primary outcome |
Countries
Sweden
Contacts
PRINCIPAL_INVESTIGATOREva Haglind, M.D., Ph.D.
SSORG
Outcome results
None listed