Dry Eye Syndromes
Conditions
Keywords
Dry Eye, Microbiome
Brief summary
The purpose of this study is to collect samples from the surface of eyelids to try to grow and identify bacteria or fungus that might be present, and to try to understand why people have dry eye symptoms.
Detailed description
Dry eye is a very common eye condition, which may or may not be caused by specific microorganisms that live on the surface of the eye. In this study, a combination of tissue culture and molecular biology techniques will be used to identify every microbe (bacteria, fungus, or virus) on the surface of eyes of people with dry eye syndrome, as well as a 'control' group of people who don't have dry eye disease.
Interventions
None listed
Sponsors
National Institutes of Health (NIH)
National Eye Institute (NEI)
University of Washington
Study design
Observational model
CASE_CONTROL
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
Yes
Inclusion criteria
* Subjects with ocular surface discomfort with an Ocular Surface Disease Index score of greater than 60 * Subjects with and Ocular Surface disease Index score less than 30 * Males and females age 18 or older
Exclusion criteria
* Contact lens wear * Use of oral or topical antibiotics in past 6 months * Use of prescription eye medication in past 6 months * Penetrating ocular or keratoplasty surgery in last 12 months * Children under the age of 18
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| To catalog the bacteria and other micro-organisms that are naturally found on the eye surface. | 6 months |
Countries
United States
Outcome results
None listed