Effect of Vit D on New-onset AF in Hypertension

Relation of Low Vitamin D Levels and New-onset AF Among Hypertensive Patients

Status

Completed

Phases

Unknown

Study type

Observational

Source

ClinicalTrials.gov

Registry ID

NCT02298738

Enrollment

227

Registered

2014-11-24

Start date

2012-01-31

Completion date

2014-11-30

Last updated

2014-11-24

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Atrial Fibrillation, Hypertension

Keywords

Atrial fibrillation, hypertension, vitamin D

Brief summary

Atrial fibrillation (AF), an important cause of cardiac mortality and morbidity is the most common type of cardiac arrhythmia in clinical practice. Hypertensive individuals are at particular risk of development of atrial fibrillation. Renin-angiotensin-aldosteron system (RAS) which is activated in hypertension may be the underlying mechanism of AF among hypertensive patients. Vitamin D deficiency has been shown to be involved in the pathogenesis of hypertension, cardiovascular disease and obesity. Increased RAS activity is one of the postulated mechanisms by which vitamin D deficiency may trigger the development of hypertension and various cardiovascular diseases. On the basis of these data we hypothesized that hypovitaminosis D might be associated with new-onset AF among patients with hypertension.

Interventions

None listed

Study design

Observational model

CASE_CONTROL

Time perspective

PROSPECTIVE

Eligibility

Sex/Gender

ALL

Age

18 Years to No maximum

Healthy volunteers

Inclusion criteria

* Hypertensive patients with new-onset AF

Exclusion criteria

Established coronary artery disease * Heart failure * Chronic obstructive pulmonary disease * Diabetes mellitus * Significant heart valve disease * Hyperthyroidism * Renal failure * Any malignancy * Acute infection * Recent thoracic or abdominal surgery * Under therapy of Vit D3

Design outcomes

Primary

Measure	Time frame	Description
hypovitaminosis D	Baseline	Identifying whether hypovitaminosis D is a risk factor for development of new-onset AF among hypertensive patients

Outcome results