Metabolic Syndrome
Conditions
Brief summary
The effect of pomegranate juice (PJ) intake on cardiovascular risks in subject with metabolic syndrome.
Detailed description
The effect of pomegranate juice (PJ) intake on cardiovascular risks in subject with metabolic syndrome in shabestar.
Interventions
OTHERpomegranate juice
Randomized clinical trial or RCT
OTHERplacebo
Randomized clinical trial or RCT
Sponsors
Urmia University of Medical Sciences
Study design
Allocation
RANDOMIZED
Intervention model
CROSSOVER
Primary purpose
SUPPORTIVE_CARE
Masking
SINGLE (Subject)
Eligibility
Sex/Gender
ALL
Age
18 Years to 70 Years
Healthy volunteers
Yes
Inclusion criteria
* presence of ≥3 of the following diagnostic of MetS: * serum TGs of at least 150 mg/dL, * waist circumference of more than 102 cm (40 in) in men and more than 88 cm (35 in) in women, * high-density lipoprotein (HDL) level less than 40 mg/dL in men and less than 50 mg/dL in women, * blood pressure 135/85 mm Hg or higher, or * fasting glucose 100 mg/dL or Higher
Exclusion criteria
* liver cirrhosis, * chronic pancreatitis, * gastrointestinal or connective diseases, * kidney stones, or * renal failure, * alcohol Consumption, * having an allergy to pomegranate juice, * a change in diet, * the large increase in LDL so that required drug treatment. * use of statins of fibrates, corticosteroids, nitrates, acetyl-salicylic acid or other anti-platelet drugs, oral hypoglycemic drugs, nonsteroidal anti-inflammatory drugs, or drugs interfering with coagulation; * pregnancy or lactation in the past 6 mo, supplementation with vitamins or antioxidants
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Change from baseline in values of metabolic syndrome components at 1 week | 1 week |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Change from baseline in values of insulin resistance (HOMA-IR), total cholesterol, LDL-C, VLDL-C and hs-CRP at 1 week | 1 weeks | Insulin resistance via HOMA-IR |
Countries
Iran
Outcome results
None listed