Healthy
Conditions
Keywords
Aerosol delivery, Lung deposition, SPECT, subjects
Brief summary
Aeroneb Solo Adapter is a vibrating-mesh nebulizer Aeroneb Solo combined to a spacer specifically designed for spontaneously breathing patients. This device has not been investigated in vivo yet. It's known that using a spacer during nebulization improves aerosol delivery. We hypothetized that lung deposition could be highly increased with the Aeroneb Solo Adapter in comparison to a standard jet nebulizer.
Interventions
Solution placed on the nebulizer reservoir
DEVICEAeroneb Solo Adapter
Nebulizer
DEVICEOpti-Mist Plus Nebulizer
Standard jet nebulizer
OTHERPlanar scintigraphy
Imaging technique to investigate whole lung deposition
OTHERSingle photon emission computed tomography
Imaging technique to investigate regional pulmonary deposition
OTHERSpirometry
FEV1, FVC assessment
Sponsors
Cliniques universitaires Saint-Luc- Université Catholique de Louvain
Study design
Allocation
RANDOMIZED
Intervention model
CROSSOVER
Primary purpose
TREATMENT
Masking
DOUBLE (Investigator, Outcomes Assessor)
Eligibility
Sex/Gender
MALE
Age
18 Years to 90 Years
Healthy volunteers
Yes
Inclusion criteria
* Healthy respiratory function
Exclusion criteria
* Pulmonary disease
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Pulmonary deposition | immediately after nebulization by imaging assessment, an expected average of 15 minutes | Planar scintigraphy and single photon emission computed tomography as imaging techiques |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Three-dimensional penetration index | immediately after the nebulization by imaging assessment, expected average of 30 minutes | Single photon emission computed tomography as imaging technique |
Other
| Measure | Time frame |
|---|---|
| Spirometry | Baseline |
Countries
Belgium
Outcome results
None listed