Serum Neuroglobin and HIF-1α in Acute Ischemic Stroke

Changes of Serum Neuroglobin and HIF-1α Concentrations in Early-phase of Acute Ischemic Stroke

Status

Completed

Phases

Unknown

Study type

Observational

Source

ClinicalTrials.gov

Registry ID

NCT02297984

Enrollment

Registered

2014-11-21

Start date

2013-10-31

Completion date

2014-10-31

Last updated

2020-08-11

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Acute Ischemic Stroke

Keywords

Neuroglobin, HIF-α, Acute ischemic stroke, Prognosis

Brief summary

Neuroglobin has shown rich neuroprotective effects against cerebral ischemia and hypoxia, and therefore has the potential to impact outcomes after acute ischemic stroke. Hypoxia inducible factor (HIF)-1α is neuroprotective in several models of experimental brain injury and is increased in brain after acute cerebral infarction in humans and experimental animals.The investigators sought to examine the changes in serum neuroglobin and HIF-1α concentrations in patients with acute ischemic stroke during the initial 96-h period after stroke and assessed the relation between them and the relation of them to prognosis of such patients with acute ischemic stroke.

Interventions

None listed

Study design

Observational model

CASE_ONLY

Time perspective

PROSPECTIVE

Eligibility

Sex/Gender

ALL

Age

42 Years to 76 Years

Healthy volunteers

Inclusion criteria

* Clinical diagnosis of acute ischemic stroke * Admission within 12 hours

Exclusion criteria

* Lacunar infarction * Cerebral hemorrhagic infarction * Epilepsy or epileptic persons * History of neurological diseases, myocardial infarction, renal and hepatic abnormalities and metabolic diseases * Contraindications to antiplatelet treatments * Serial blood samples could not be obtained

Design outcomes

Primary

Measure	Time frame	Description
Modified Rankin Scale scores	3 months	0 = No symptoms; 1 = No significant disability. Able to carry out all usual activities, despite some symptoms; 2 = Slight disability. Able to look after own affairs without assistance, but unable to carry out all previous activities; 3 = Moderate disability. Requires some help, but able to walk unassisted; 4 = Moderately severe disability. Unable to attend to own bodily needs without assistance, and unable to walk unassisted; 5 = Severe disability. Requires constant nursing care and attention, bedridden, incontinent; 6 = Dead.

Secondary

Measure	Time frame	Description
Glasgow Outcome Scale scores	3 months	Glasgow Outcome Scale 1 = death; Glasgow Outcome Scale 2 = vegetative state; Glasgow Outcome Scale 3 = severe neurological deficit; Glasgow Outcome Scale 4 = mild neurological deficit and Glasgow Outcome Scale 5 = premorbid level of functioning or completely recovery.

Countries

China

Outcome results