Exercise Training in Patients With Chagasic Heart Disease Without Ventricular Dysfunction

Effects of Physical Training on Sensitivity Baroreflex Patients Without Chagas' Heart Ventricular Systolic Dysfunction

Status

UNKNOWN

Phases

Study type

Interventional

Source

ClinicalTrials.gov

Registry ID

NCT02295215

Acronym

CH0660/10

Enrollment

Registered

2014-11-20

Start date

2013-06-30

Completion date

2015-12-31

Last updated

2014-11-20

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Chagas Disease

Keywords

chagas disease, exercise, baroreflex sensitivity

Brief summary

The prevalence of Chagas' disease continues high even in the developed countries. Chagasic Cardiomyopathy with preserved ventricular function is an understudied form of Chagas disease. Since a majority of patients with these changes progress to dilated form with ventricular dysfunction with all its serious consequences, it is interesting to better understand the pathophysiology of the disease at the stage where there electrocardiographic changes and preserved ventricular function. And besides, search strategies to slow the progress, or even prevent the chronic phase of the disease. For this reason the investigators will evaluate the effects of exercise training in patients with Chagas cardiomyopathy without ventricular dysfunction.

Detailed description

Chagasic Cardiomyopathy with preserved ventricular function is an understudied form of Chagas disease. Since a majority of patients with these changes progress to dilated form with ventricular dysfunction with all its serious consequences, it is interesting to better understand the pathophysiology of the disease at the stage where there electrocardiographic changes and preserved ventricular function. And besides, search strategies to slow the progress, or even prevent the chronic phase of the disease. For this reason the investigators will evaluate the effects of exercise training in patients with Chagas cardiomyopathy without ventricular dysfunction.

Interventions

OTHERExercise

Exercise Training for 4 months

Study design

Allocation

RANDOMIZED

Intervention model

PARALLEL

Primary purpose

TREATMENT

Masking

NONE

Eligibility

Sex/Gender

ALL

Age

25 Years to 60 Years

Healthy volunteers

Inclusion criteria

* Chagas' disease patients, diagnosed with at least two positive serological reactions to Chagas' disease, * Ejection fraction ≥55%

Exclusion criteria

* Participation in a regular exercise program in the last 3 months preceding the survey * Use of oral anticoagulant * Use of a pacemaker or implantable cardioverter * Hemodynamic instability * Myocardial revascularization infarction or unstable angina in the last 3 months of the start of the protocol * Diabetes mellitus * Hypertension * Pulmonary Disease * Valvular lesions * Atrial Fibrillation * Angina of effort

Design outcomes

Primary

Measure	Time frame	Description
Sympathetic nerve activityAutonomic control	4 months	Exercise training will improve baroreflex sensitivity and reduce sympathetic nerve activity.

Secondary

Measure	Time frame	Description
Peak oxygen consumption	4 months	Exercise training will improve peak oxygen consumption
Skeletal muscle strength	4 months	Exercise training will increase skeletal muscle strength

Countries

Brazil

Contacts

Primary ContactCarlos E Negrão

cndnegrao@incor.usp.br5511 26615699

Backup ContactAdriana S Oliveira

adriana.sarmento@usp.br5511 26615057

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 26, 2026