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Knee Stiffness in Fibrosis Diathesis

Does Fibrosis Diathesis Influence the Recovery of Knee Mobility After Total Knee Replacement?

Status
UNKNOWN
Phases
Unknown
Study type
Observational
Source
ClinicalTrials.gov
Registry ID
NCT02294890
Enrollment
60
Registered
2014-11-19
Start date
2015-01-31
Completion date
2015-04-30
Last updated
2014-11-19

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Dupuytren's Disease, Fibrosis, Knee Replacement Arthroplasty

Brief summary

At the standard follow-up moment one year after primary TKA for gonarthrosis, all patients will be checked for signs of fibrosis diathesis. This will be done by examining their hands for Dupuytren's nodules and contractures and recording risk factors associated with increased severity and risk of recurrence of Dupuytren's contracture. These include family history, bilateral DD, and ectopic lesions, age of onset less than 50 years, male gender, Ledderhose disease, first ray involvement, multiple ray involvement and ectopic fibromatosis. This way, two groups of patients will be identified: those with and those without signs of fibrosis diathesis. For both groups, the range of motion (ROM) of the operated knee at 3 and 6 months will be retrieved in the charts, the ROM at 12 months will be measured at that time. Also, additional procedures performed to increase ROM postoperatively will be retrieved from the charts (e.g. continuous passive motion, mobilization under anesthesia). Other causes for knee stiffness will have to be recorded, since these will be the most important exclusion criteria. In the patients with clear signs of finger contractures, any impression of increase of contracture over the past 12 months will be recorded.

Interventions

PROCEDURETotal knee arthroplasty

Sponsors

University Hospital Pellenberg
Lead SponsorOTHER

Study design

Observational model
COHORT
Time perspective
RETROSPECTIVE

Eligibility

Sex/Gender
ALL
Age
50 Years to No maximum
Healthy volunteers
No

Inclusion criteria

* All patients undergoing a total knee replacement for primary gonarthrosis with a minimum follow-up of 1 year

Exclusion criteria

* Patients undergoing a TKA for other reasons than primary gonarthrosis, e.g. after infection, posttraumatic arthritis,hemophilia,… * Patients who had other problems after their TKA resulting in knee stiffness, e.g. infection, bleeding,…

Design outcomes

Primary

MeasureTime frame
Range of movement of the operated knee at 12 months postoperatively12 months
Additional procedures/interventions to gain motion12 months

Secondary

MeasureTime frame
- Increase of contracture or appearance of the nodules and contractures in the hand after the knee surgery.12 months
KSS score for knee function12 months

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026