Outcome of Three Controlled Ovarian Hyperstimulation Protocols in Poor Responding Infertility Patients

Status

Completed

Phases

Study type

Interventional

Source

ClinicalTrials.gov

Registry ID

NCT02293668

Enrollment

Registered

2014-11-18

Start date

2014-11-30

Completion date

2015-08-31

Last updated

2016-01-08

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Infertility

Keywords

poor responders

Brief summary

There are different controlled ovarian hyperstimulation protocols utilized in infertility patients. In this study, our aim is to specifically compare three protocols in poor responding infertility patients.

Interventions

DRUGFSH 225IU and hMG 225IU

DRUGFSH 150IU and hMG 150IU

DRUGLetrozole 5mg and hMG 150IU

Study design

Allocation

RANDOMIZED

Intervention model

PARALLEL

Primary purpose

TREATMENT

Masking

NONE

Eligibility

Sex/Gender

FEMALE

Age

18 Years to 42 Years

Healthy volunteers

Inclusion criteria

* Patients will be considered eligible if they are poor ovarian responders according to the Bologna criteria (Ferraretti et al., 2011). * Two out of three of the following criteria are essential in order to classify a patient as poor ovarian responder: * advanced maternal age (≥40 years) or any other risk factor for poor ovarian response; * a poor ovarian response (≤3 oocytes with a conventional stimulation protocol); or * an abnormal ovarian reserve test (antral follicle count, \<7 follicles or anti-Mullerian hormone, \<1.1 ng/ml).

Design outcomes

Primary

Measure	Time frame
Clinical pregnancy rate	8 weeks

Secondary

Measure	Time frame
Number of oocytes retrieved	4 weeks
Number of transferable embryos	4 weeks
Biochemical pregnancy rate	6 weeks

Countries

Turkey (Türkiye)

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026