24 Hrs Histamine Profile in Healthy Persons and Patients With Food Intolerance

24 Hrs Histamine Profile in Healthy Persons and Patients With Food Intolerance: Correlations Between Subjective Affliction and Measured Histamine Parameter

Status

Completed

Phases

Unknown

Study type

Observational

Source

ClinicalTrials.gov

Registry ID

NCT02293343

Enrollment

Registered

2014-11-18

Start date

2014-10-31

Completion date

2017-05-31

Last updated

2017-05-11

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Allergy, IBS

Keywords

histamine profile, IgE Antibodies

Brief summary

Over 24 hrs serum and plasma samples were collected every 3 hrs. With this a day histamine profile was created. 15 healthy persons with 20 patients with a high level of IgE in serum and 20 patients with afflictions but no high IgE level were compared. Measurment of histamine in plasma, urine and stool were realized. In addition to that Diaminoxidase, TNF alpha and IgE Antibodies were measured.

Interventions

OTHERblood profile

Study design

Observational model

CASE_CONTROL

Time perspective

PROSPECTIVE

Eligibility

Sex/Gender

ALL

Age

18 Years to 70 Years

Healthy volunteers

Yes

Inclusion criteria

* healthy subjects * appropriate invalid persons

Exclusion criteria

* pregnant and weaning persons

Design outcomes

Primary

Measure	Time frame
Histamine	24 hrs

Secondary

Measure	Time frame
diaminoxidase	24 hrs

Other

Measure	Time frame
TNF alpha	24 hrs
IgE	24 hrs

Countries

Germany

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026