Cardiovascular Diseases
Conditions
Keywords
flow-mediated dilation, Acai polyphenols
Brief summary
The purpose of this study is to carry out a randomized double blind controlled trial in 30 male subjects to investigate the effect of acai consumption on acute changes in vascular function, and to other cardiovascular markers. As a secondary aim the study will allow us to characterize the absorption and metabolism of acai polyphenols in humans over a 24 hour period.
Interventions
DIETARY_SUPPLEMENTControl Macronutrient matched
Macronutrient matched control in water and also prepared with banana.
DIETARY_SUPPLEMENTAcai puree, frozen blended it with banana
150g of acai fruit, frozen blended it with banana.
Sponsors
University of Reading
Study design
Allocation
RANDOMIZED
Intervention model
CROSSOVER
Primary purpose
BASIC_SCIENCE
Masking
DOUBLE (Subject, Investigator)
Eligibility
Sex/Gender
MALE
Age
30 Years to 65 Years
Healthy volunteers
Yes
Inclusion criteria
* Male, 30-65 aged, BMI 25-35 kg/m2, Cholesterol \<8 mmol/l.
Exclusion criteria
* Female, BMI \<25 or \>35 kg/m2, Cholesterol \>8mmol l-1, elevated fasting blood sugar \> 6.5 mmols l-1 , elevated systolic blood pressure \>150 mmHg, history of stroke or heart attack within the previous 12 months, current smoking, taking lipid lowering, blood pressure lowering or anti-blood clotting medication or taking micronutrient supplements.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Flow-mediated dilation | Change from baseline to 2h |
Secondary
| Measure | Time frame |
|---|---|
| plasma polyphenol metabolites | Change from baseline to 24h |
Countries
United Kingdom
Outcome results
None listed