Type 2 Diabetes
Conditions
Keywords
anthocyanin, blackcurrant, greencurrant, glucose, polyphenol, post prandial glucose
Brief summary
Dietary strategies for alleviating health complications associated with type 2 diabetes (T2D) are being pursued as alternatives to pharmaceutical interventions. Berries such as blackcurrants that are rich in polyphenols may influence carbohydrate digestion and absorption and thus postprandial glycaemia. In addition berries have been reported to alter incretins as well as to have anti-oxidant and anti-inflammatory properties that may also affect postprandial glycaemia. This study investigated the acute affect blackcurrants on glucose metabolism in overweight/obese volunteers .
Detailed description
Sixteen overweight/obese volunteers from the Aberdeen area will be recruited into a randomised controlled study. Volunteers will be randomised into four groups matched for BMI and age and given 200 grams of blackcurrants (which contain anthocyanins) or greencurrants (which naturally contain no anthocyanins), followed by an OGTT. The consumption of the currants will be followed by an oral glucose tolerance test (OGTT) with Polycal (complex carbohydrate) or glucose (simple carbohydrate) as the carbohydrate load. There will be a one week minimum wash out period between each intervention. All interventions will be randomised and blinded as far as possible in a cross-over design where the volunteers are acting as their own control. The volunteers will be asked to consume a low phytochemical diet three days prior to taking the currants all occasions. In addition, they will be asked to record what they ate over the same period in a simple food diary. The following intervention will be carried out on 16 overweight/obese male/postmenopausal female non-smoker volunteers: 1. Control: sugar matched (matched to currant sugar content) water with polycal (complex carbohydrate load) 2. Blackcurrants (which contain anthocyanins; 200grams) with polycal (complex carbohydrate load) 3. Blackcurrants (which contain anthocyanins; 200grams) with glucose (simple carbohydrate load) 4. Greencurrants (which naturally contain no anthocyanins; 200grams) with polycal (complex carbohydrate load) Note: the polycal will contain the equivalent glucose load as given in intervention 3 assuming complete hydrolysis of all carbohydrates.
Interventions
DIETARY_SUPPLEMENTBlackcurrants with glucose OGTT
Sixteen overweight/obese volunteers from the Aberdeen area will be recruited into a randomised controlled study. Volunteers will be randomised into four groups matched for BMI and age and given 200 grams of blackcurrants (which contain anthocyanins) or greencurrants (which naturally contain no anthocyanins), followed by an OGTT. The consumption of the currants will be followed by an oral glucose tolerance test (OGTT) with Polycal (complex carbohydrate) or glucose (simple carbohydrate) as the carbohydrate load. The equivalent carbohydrate load will be standardised across the groups
DIETARY_SUPPLEMENTBlackcurrants with polycal OGTT
Sixteen overweight/obese volunteers from the Aberdeen area will be recruited into a randomised controlled study. Volunteers will be randomised into four groups matched for BMI and age and given 200 grams of blackcurrants (which contain anthocyanins) or greencurrants (which naturally contain no anthocyanins), followed by an OGTT. The consumption of the currants will be followed by an oral glucose tolerance test (OGTT) with Polycal (complex carbohydrate) or glucose (simple carbohydrate) as the carbohydrate load. The equivalent carbohydrate load will be standardised across the groups
DIETARY_SUPPLEMENTGreencurrants with polycal OGTT
Sixteen overweight/obese volunteers from the Aberdeen area will be recruited into a randomised controlled study. Volunteers will be randomised into four groups matched for BMI and age and given 200 grams of blackcurrants (which contain anthocyanins) or greencurrants (which naturally contain no anthocyanins), followed by an OGTT. The consumption of the currants will be followed by an oral glucose tolerance test (OGTT) with Polycal (complex carbohydrate) or glucose (simple carbohydrate) as the carbohydrate load. The equivalent carbohydrate load will be standardised across the groups
DIETARY_SUPPLEMENTSugar matched water with polycal OGTT
Sixteen overweight/obese volunteers from the Aberdeen area will be recruited into a randomised controlled study. Volunteers will be randomised into four groups matched for BMI and age and given 200 grams of blackcurrants (which contain anthocyanins) or greencurrants (which naturally contain no anthocyanins), followed by an OGTT. The consumption of the currants will be followed by an oral glucose tolerance test (OGTT) with Polycal (complex carbohydrate) or glucose (simple carbohydrate) as the carbohydrate load. The equivalent carbohydrate load will be standardised across the groups
Sponsors
University of Aberdeen
Study design
Allocation
RANDOMIZED
Intervention model
CROSSOVER
Primary purpose
TREATMENT
Masking
SINGLE (Subject)
Eligibility
Sex/Gender
ALL
Age
21 Years to 70 Years
Healthy volunteers
Yes
Inclusion criteria
* Obese male or female (postmenopausal) healthy non-smoking volunteers (BMI over 25kg/m2) * Aged \>21 and \<70 years
Exclusion criteria
* Medical
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Plasma Glucose Area Under the Curve | Plasma was collected at -15, -10 and -5 (fasted) and at 15, 30, 45, 60, 90, 120, 150 and 300 min post currant ingestion |
Secondary
| Measure | Time frame |
|---|---|
| Plasma Insulin Area Under the Curve | Plasma was collected at -15, -10 and -5 (fasted) and at 15, 30, 45, 60, 90, 120, 150 and 300 min post currant ingestion |
Countries
United Kingdom
Contacts
Primary ContactNigel Hoggard, PhD
Outcome results
None listed