Retinal Oxygen Saturation in Patients With Graves' Ophthalmopathy and in Normal People

Changes of Retinal Oxygen Saturation in Patients With Graves' Ophthalmopathy Under Different Managing Conditions and in Normal People

Status

UNKNOWN

Phases

Unknown

Study type

Observational

Source

ClinicalTrials.gov

Registry ID

NCT02290704

Enrollment

200

Registered

2014-11-14

Start date

2014-01-31

Completion date

2017-11-30

Last updated

2017-11-28

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Graves' Ophthalmopathy

Keywords

oxygen saturation, retinal vessels, thyroid associated ophthalmopathy

Brief summary

Find if the retinal function is affected in both the nonsevere and the severe stage of Graves' ophthalmopathy (GO) by comparing the retinal oxygen saturation of GO patients with that of normal people.

Detailed description

Graves'ophthalmopathy (GO), also called thyroid-associated ophthalmopathy, is often mild and self-limiting, and probably declining in frequency, with only 3-5% of cases posing a threat to eyesight, remaining a pathogenetic enigma and a therapeutic dilemma. In its nonsevere expression, the symptoms and signs include Photophobia, Foreign body sensation, Eyelid retraction, increased intraocular pressure, Lagophthalmos, and Mild diplopia. In its severe expression, it is a disfiguring and invalidating disease with the optic nerve damaged. However, in this study, we want to find if the retinal vessels is affected in the early stage of the disease through observing the oxygen saturation of the retinal vessels and compare it with that of the normal people.

Interventions

None listed

Study design

Observational model

OTHER

Time perspective

PROSPECTIVE

Eligibility

Sex/Gender

ALL

Age

18 Years to No maximum

Healthy volunteers

Yes

Inclusion criteria

for GO patients: 1. conforms to the diagnosis of Graves' ophthalmopathy; 2. age \> 18; 3. volunteered to participate in this research, and sign the informed consent. Inclusion Criteria for Control group: 1. age \> 18; 2. diopter within + / - 3D; 3. volunteered to participate in this research, and sign the informed consent.

Exclusion criteria

for GO patients: 1. Fundus could not be seen clearly; 2. pregnant and lactating women; 3. could not tolerate the examination.

Design outcomes

Primary

Measure	Time frame
changes of retinal oxygen saturation in patients with GO under different managing conditions	before surgery ( or glucocorticoids administration), 1 week and 4 weeks after surgery ( or glucocorticoids administration)

Countries

China

Contacts

Primary ContactDanping Huang

hdanp@mail.sysu.edu.cn+8613501508328

Backup ContactXiaonan Yang

yangxn3@mail2.sysu.edu.cn+8613751859797

Outcome results