Obstructive Lung Diseases
Conditions
Keywords
obstructive pulmonary disease, children, teenager, EIT (Electrical Impedance Tomography)
Brief summary
The investigator will determine a compliance of two diagnostic techniques (EIT and Body plethysmography) in collective of children and teenagers with obstructive lung disease and a matched control group.
Detailed description
The aim of the present study is verification of the correlation between EIT-derived data and following extracted parameters of the pulmonary function: * forced expiratory volume in 1 second (FEV 1) * forced vital capacity (FVC) * relative forced expiratory volume in 1 second (FEV1/FVC) * maximal expiratory flow (MEF 25) * total lung capacity (TLC) * resistance (Raw). These findings could bring out new prospective opportunity for pulmonary function tests without cooperation. Furthermore, the study aims to clarify whether EIT technique can be used for regional pulmonary function testing. In addition, dynamic lung function parameter and static radiological techniques will be correlated with EIT.
Interventions
PROCEDUREpatients
The 16-electrode belt will be applied to patient's chest. Following vital signs will be recorded: respiratory rate at rest breathing, heart rate, transcutaneous oxygen saturation. Then impulse oscillometry (IOS) will be performed in a sitting position. After that, subjects with cooperation willingness will get a body plethysmography. A spirometry / forced breathing maneuvers will be performed. All patients will receive 2 strokes salbutamol inhaler for bronchospasmolysis. Please note that inhalation of salbutamol is not study related. It is used in the clinical routine to examine the reversibility of the bronchial obstruction in patients with obstructive lung disease in course of the lung function test. Ten minutes later measurements described above will be repeated.
PROCEDUREprobands
Probands will receive the same treatment as patients, but without bronchospasmolysis.
Sponsors
RWTH Aachen University
Study design
Observational model
CASE_CONTROL
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
5 Years to 18 Years
Healthy volunteers
Yes
Inclusion criteria
* Patients: children and teenagers with obstructive pulmonary disease (asthma, cystic fibrosis, immotile-cilia-syndrome, obstructive brochitis, obstructive pneumonia). * Probands: Children and Teenager of 5-18 years without known obstructive pulmonary diseases
Exclusion criteria
* active implants (ICD, CRT) * metal in chest * artificial heart valve * children \< 5 years * pregnant and lactating females * Persons, who are in relationship of dependence to the investigator / sponsor * Persons, who are not able to understand and follow the instructions of the study personnel. * Lack of signed informed consent (by legal guardian /proband)
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Robustness of change in electrical impedance based on the forced expiratory volume in 1 second (ΔZFEV01) | Baseline | The robustness of ΔZFEV1.0 (= change in electrical impedance based on the FVC FEV1.0) and τ (= mechanical time constant τ which classifies the regional and global lung mechanics) and their clinical relevance will be investigated. |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Correlation between lung function parameters and extracted parameters of the EIT. | Baseline | The present study aims to verify, whether a correlation between lung function parameters and extracted parameters of the EIT exists. |
| EIT as a diagnostic method for assessment of lung function | Baseline | It will be examined, whether single EIT measurement can be used for assessment of the lung function. |
| Regional mechanical transmission behavior | Baseline | Another secondary outcome is the local mechanical transmission behavior as an index of pulmonary status. By using the correlation between results gained from EIT and results from impulse oscillometry (IOS) differentiation between central and peripheral obstruction of respiratory tracts will be proved. |
Countries
Germany
Outcome results
None listed