Central Airway Stenosis, Noninvasive Positive Pressure Ventilation;, Sedation;, Bronchoscopy；, Interventional；
Conditions
Brief summary
To evaluate the effect and safety of noninvasive ventilation assisted interventional bronchoscopy for hypoxemia patients with central airway stenosis. With the sedation and analgesia, noninvasive ventilation assisted interventional bronchoscopy for hypoxemia patients with central airway stenosis is safe and effective, carries high satisfaction rate.
Interventions
PROCEDUREinvasive ventilation
PROCEDUREinterventional bronchoscopy
DEVICEnoninvasive ventilation
DRUGsedation(dezocine and midazolam)
DRUGgeneral anesthesia(midazolam, fentanyl，rocuronium，propofol and Remifentanil）
Sponsors
Science and Technology Innovation Commission of Shenzhen Municipality
Futian People's Hospital
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT
Masking
NONE
Eligibility
Sex/Gender
ALL
Healthy volunteers
No
Inclusion criteria
* (a)patients with central airway stenosis need interventional bronchoscopy. (b) partial pressure of arterial oxygen (PaO2)/fraction of inspired oxygen (FiO2) ratio less than 300;
Exclusion criteria
* (a) facial deformity sufficient to preclude mask fitting; (b) upper gastrointestinal bleeding; (c) upper airway obstruction; (d) acute coronary syndromes; (e) tracheostomy or endotracheal intubation(ETI) before admission; (f) need for urgent ETI due to cardiac or respiratory arrest.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| The improvement of airway stenosis after the operation | 1 day |
| The improvement of partial pressure of arterial oxygen (PaO2) after the operation | 1 day |
Secondary
| Measure | Time frame |
|---|---|
| hospitalization expenses | During the period of hospitalization，an expected average of 4 weeks |
| hypoxemia during the operation | 1 day |
Countries
China
Contacts
Primary ContactXiao-ke Chen, Master
Outcome results
None listed