Chronic Obstructive Pulmonary Disease
Conditions
Brief summary
Chronic obstructive pulmonary disease(COPD) is a common disease among people. Acute exacerbation of chronic obstructive pulmonary disease(AECOPD) is the acute and aggravating phase of COPD which may lead to respiratory failure. Mechanical ventilation is a very important therapy for those patients,but traditional ventilation modes have some defects, so investigators need to find new modes to solve these problems. In this study, the investigators compare neurally adjusted ventilatory assist (NAVA) and PSV to observe the effects on AECOPD patients' air distribution and dead space to determine if NAVA is a more appropriate ventilation mode for AECOPD patients.
Interventions
DEVICENAVA and PSV
change ventilation modes(NAVA and PSV) with different support levels
Sponsors
Southeast University, China
Study design
Allocation
NON_RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT
Masking
NONE
Eligibility
Sex/Gender
ALL
Age
18 Years to 75 Years
Healthy volunteers
No
Inclusion criteria
* AECOPD patients who need invasive mechanical ventilation * Patients who can tolerate assist mechanical ventilation * Patients who have signed ICF
Exclusion criteria
* Patients who are younger than 18 years old or older than 75 years old * Patients whose respiratory center is severely inhibited * Patients who can not stand NAVA gastric tube * Patients who have coagulation disorders * Patients whose vital signs are unstable * Patients who are in other clinical trails
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| the ratio of physiologic dead space over tidal volume (VD/VT) | 1 year |
Outcome results
None listed