Chronic Pain
Conditions
Keywords
Chronic pain, Morphine, Dexmedetomidine
Brief summary
The purpose of this study is to determine whether dexmedetomidine added to morphine is effective in the treatment of chronic cancer pain.
Detailed description
We conduct the study in Cukurova University Faculty of Medicine Research Hospital after obtaining ethics committee approval and patient's informed consent. Patients with cancer pain are allocated into two group to receive Patient Controlled Analgesia with morphine or morphine plus dexmedetomidine.
Interventions
DRUGMorphine
Morphine, 0.02 mg/kg PCA bolus dose with 10 minutes lock-out interval
DRUGMorphine plus dexmedetomidine
Morphine 0.02 mg/kg plus dexmedetomidine 0.1 microgram/kg PCA bolus dose with 10 minutes lock-out interval
Sponsors
Cukurova University
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT
Masking
DOUBLE (Subject, Investigator)
Eligibility
Sex/Gender
ALL
Age
20 Years to 80 Years
Healthy volunteers
No
Inclusion criteria
* patients with chronic cancer pain * between 20-80 years old age
Exclusion criteria
* the presence of severe systemic disease(cardiac, pulmonary, hepatic or renal) * psychiatric or neurologic disease * unable to communicate verbally * nausea and vomiting * patient's refusal
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Morphine consumption (mg) | 24 hours | cumulative morphine consumption for 24 hours |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Pain score | 24 hours | visual analog scale to assess pain degree |
Countries
Turkey (Türkiye)
Outcome results
None listed