Acid Base Balance of ICU Patients With Severe Hypoalbuminemia, Before and After an Albumin Infusion, Using Stewart Approach

Status

UNKNOWN

Phases

Unknown

Study type

Observational

Source

ClinicalTrials.gov

Registry ID

NCT02288494

Acronym

STEWALB

Enrollment

100

Registered

2014-11-11

Start date

2013-10-31

Completion date

2014-11-30

Last updated

2014-11-11

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Adult ICU Patient, Human Albumin Perfusion, Hypoalbuminemia, Stewart Approach for Acid Base Disorders

Keywords

hypoalbuminemia, -acid base balance, acid base disorders, critical ill, Stewart approach, human albumin infusion

Brief summary

The primary purpose was to describe the acid base balance of ICU patients with severe hypoalbuminemia using Stewart's approach for acid base disorders, before and after an human albumin perfusion.

Detailed description

Prospective study, for ICU patient with severe hypoalbuminemia \< 20g/L, determining biological parameters from Stewart approach for acid base disorders (pH, SIDe, SIDa, SIG, Atot, PaCO2) before, and at 1hour, 2hours and 24 hours after a 200mL 20% human albumin perfusion (the consensus conference ANAES of 1995 recommands to correct hypoalbuminemia below 20g/L). Clinical parameters (respiratory, haemodynamic, neurologic) were also collected at the same times.

Interventions

OTHERstewart approach

Prospective study, for ICU patient with severe hypoalbuminemia \< 20g/L, determining biological parameters from Stewart approach for acid base disorders (pH, SIDe, SIDa, SIG, Atot, PaCO2) before, and at 1hour, 2hours and 24 hours after a 200mL 20% human al Clinical parameters (respiratory, haemodynamic, neurologic) were also collected at the same times.

Study design

Time perspective

CROSS_SECTIONAL

Eligibility

Sex/Gender

ALL

Age

18 Years to No maximum

Healthy volunteers

Inclusion criteria

* serum albuminemia \< 20g/L * adult ICU patient * Arterial line

Exclusion criteria

* albumin allergy * pregnancy * congestive heart failure

Design outcomes

Primary

Measure	Time frame
changes in pH and independent pH determinants using Stewart approach	at 1 hour, 2 hours and 24 hours after a 200mL of 20% human albumin perfusion.

Secondary

Measure	Time frame
changes in neurologic parameters	at 1 hour, 2 hours and 24 hours after a 200mL of 20% human albumin perfusion.
changes in hemodynamic parameters	at 1 hour, 2 hours and 24 hours after a 200mL of 20% human albumin perfusion.
changes in respiratory parameters	at 1 hour, 2 hours and 24 hours after a 200mL of 20% human albumin perfusion.

Countries

France

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026