Exercise Therapy
Conditions
Brief summary
The purpose of this RCT is to study the effects of whole muscle training (inspiratory muscle training + aerobic training + muscle resistance training) on muscle power, VO2peak and gas-exchange variables obtained during cardiopulmonary exercise testing, QoL, functional capacity (eg, 6-min walking distance), and maximal inspiratory pressure in patients with pulmonary artery hypertension.
Interventions
OTHERexercise
Exercise training for 8 weeks (aerobic exercise, resistance training and inspiratory muscle training thrice a week)
Sponsors
Universidad Europea de Madrid
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT
Masking
SINGLE (Outcomes Assessor)
Eligibility
Sex/Gender
ALL
Age
18 Years to 65 Years
Healthy volunteers
No
Inclusion criteria
* Diagnosed pulmonary hypertension, class II-III NYHA, no syncope in the last 3 months (stable clinical condition) or chronic thromboembolic pulmonary hypertension
Exclusion criteria
* Not meeting the above
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Muscle power (upper and lower-body) | 8 weeks |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| maximal inspiratory pressure (PImax) | 8 weeks | — |
| Short Form 36-Item Health Survey questionnaire version 2 (SF-36) | 8 weeks | — |
| Physical activity levels objectively determined with accelerometry | 8 weeks | — |
| Peak oxygen uptake (VO2peak) directly measured during cardiopulmonary exercise testing (CEPT) | 8 weeks | — |
| 6 minute walk distance test | 8 weeks | — |
| NT-ProBNP | 8 weeks | — |
| Performance in the 5-repetition sit-stand-test (5SST) | 8 weeks | — |
| Safety assessment | 8 weeks | Evaluation of adverse episodes, ie. syncopal/pre-syncopal episodes, severe dyspnea, arrhythmias, asthma, signs of poor peripheral perfusion or central nervous symptoms (ataxia, tremors). These episodes were be reported directly by the study researchers (in the exercise group) and by a telephone interview every 2 weeks in all participants. |
| Other CEPT variables | 8 weeks | Gas-exchange variables at the anaerobic threshold |
Countries
Spain
Outcome results
None listed