Combined Administration of Intravenous and Topical Tranexamic Acid in Total Knee Arthroplasty

Combined Administration of Intravenous and Topical Tranexamic Acid in Total Knee Arthroplasty: Is it the Most Effective Regime? A Randomized Controlled Trial.

Status

UNKNOWN

Phases

Phase 1

Study type

Interventional

Source

ClinicalTrials.gov

Registry ID

NCT02286973

Enrollment

264

Registered

2014-11-10

Start date

2014-11-30

Completion date

2015-06-30

Last updated

2014-11-10

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Degenerative Arthritis

Keywords

Tranexamic acid

Brief summary

This prospective randomized controlled trial was conducted To compare the efficacy of TNA in terms of total blood loss and the allogenic transfusion rate among the three study groups; intravenous alone, combined intravenous and low dose topical TNA and combined intravenous and high dose topical TNA. To evaluate the safety of each regimen in view of deep vein thrombosis and venous thromboembolism.

Interventions

DRUGTranexamic Acid

Study design

Allocation

RANDOMIZED

Intervention model

PARALLEL

Primary purpose

PREVENTION

Masking

SINGLE (Subject)

Eligibility

Sex/Gender

ALL

Age

50 Years to No maximum

Healthy volunteers

Yes

Inclusion criteria

* patients with diagnosis of primary osteoarthritis

Exclusion criteria

* patients with diagnoses other than primary OA * patients on anticoagulation therapy * patient with chronic renal failure * patient with CVA Hx * Patient with seizure Hx * Patient with severe CHF * Patient with acquired or congenital coagulopathy

Design outcomes

Primary

Measure	Time frame	Description
Change in Hemoglobin	baseline and 5 days	Blood loss reduce

Contacts

Primary ContactTaeKyun Kim, MD,PhD

osktk@gmail.com082-031-787-3355

Backup ContactSungyup Lee, MD

oslsy1204@gmail.com082-031-787-6480

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026