Global Strain and Mechanical Dispersion May Predict Death and Ventricular Arrhythmias Better Than Ejection Fraction

Improved Prediction of Clinical Outcome With the Use of Global Strain and Mechanical Dispersion in Patients With Myocardial Infarction and Heart Failure

Status

UNKNOWN

Phases

Unknown

Study type

Observational

Source

ClinicalTrials.gov

Registry ID

NCT02286908

Enrollment

3100

Registered

2014-11-10

Start date

2014-06-30

Completion date

2025-12-31

Last updated

2023-11-13

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Left Ventricular Function Systolic Dysfunction

Keywords

Ejection fraction, Global Strain, Mechanical dispersion

Brief summary

The aim of the study is to investigate if global strain and mechanical dispersion may predict death and ventricular arrhythmias better than ejection fraction(EF) in patients with myocardial infarction and heart failure regardless of cause.

Detailed description

1. The main aim of this study is to investigate if global strain and mechanical dispersion may predict death and ventricular arrhythmias better than left ventricular ejection fraction in patients with myocardial infarction and heart failure. 2. In patients who receive internal cardioverter defibrillator(ICD) the main aim is to investigate if mechanical dispersion may predict ventricular arrhythmias better than EF. 3\) No interventions,only evaluation of the measurements obtained with transthoracic echocardiography. 4\) Follow up for 3 years, extended from 3 to 5 years.

Interventions

None listed

Study design

Observational model

OTHER

Time perspective

PROSPECTIVE

Eligibility

Sex/Gender

ALL

Age

18 Years to No maximum

Healthy volunteers

Inclusion criteria

* All patients with 1. myocardial infarction 2. heart failure( defined as heart failure symptoms: reduced left ventricular function/ and or heart failure signs on chest x ray. 3. planned for primary prophylactic ICD * over 18 years of age * Informed consent

Exclusion criteria

Design outcomes

Primary

Measure	Time frame	Description
Ventricular arrhythmia and death after acute myocardial infarction or heart failure.	5 years or more	Arrhythmic events during follow-up are defined as documented sustained ventricular tachycardia, ventricular fibrillation, and SCD. Survival is assessed by medical charts if patients are within the uptake area of the hospital and by the Norwegian death registry Folkeregisteret.

Countries

Czechia, Norway

Contacts

Primary ContactThor Edvardsen, MD, PHD

thor.edvardsen@medisin.uio.no

Backup ContactHarald Brunvand, MD, PHD

harbrun@online.no

Outcome results