Injection Pain
Conditions
Brief summary
Propofol remains the most common drug for induction of general anaesthesia, although it causes considerable pain or discomfort on injection. Anesthesia providers have attempted a large number of remedies to prevent this pain on injection. Previously explored ideas include injecting propofol into larger veins, warming of the hand with hot packs, and intravenous pretreatment with numerous other medications. No studies to date have looked at the dexketoprofen and tenoxicam for the pretreatment of pain on injection caused by propofol. The investigators propose studying the use of dexketoprofen and tenoxicam for pretreatment of propofol related pain on injection.
Interventions
DRUGsaline
before the anesthesia induction, 2mL saline iv injection
DRUGdexketoprofen
before the anesthesia induction, 50 mg (2mL) iv dexketoprofen
DRUGtenoxicam
before the anesthesia induction, 20 mg (2mL) iv tenoxicam
Sponsors
Ordu University
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
PREVENTION
Masking
DOUBLE (Subject, Outcomes Assessor)
Eligibility
Sex/Gender
ALL
Age
18 Years to 65 Years
Healthy volunteers
No
Inclusion criteria
* American Society of Anesthesiologists (ASA) physical status 1 and 2 * 18 - 65 years * general anesthesia scheduled for elective surgery
Exclusion criteria
* age \< 18 years, \> 65 years * pregnancy * patients requiring a rapid sequence induction * refusal to participate and patients already participating in another study * allergy to study drugs * communication difficulty * psychiatric and neurolojic disorders * use of analgesics or sedative drugs within 24 hours before surgery. * emergency surgery * history of drug or alcohol abuse * ASA 3 and above
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Verbal Pain Score | Approximately one minute following administration of propofol. |
| Facial Pain Score | Approximately one minute following administration of propofol. |
Countries
Turkey (Türkiye)
Outcome results
None listed