Can 10 Seconds Inspiratory Hold Open Atelectasis in Mechanically Ventilated Patients?

Can 10 Seconds Inspiratory Hold Open Atelectasis in Mechanically Ventilated Patients? A Pilot Study.

Status

UNKNOWN

Phases

Study type

Interventional

Source

ClinicalTrials.gov

Registry ID

NCT02285894

Enrollment

Registered

2014-11-07

Start date

2014-11-30

Completion date

2015-08-31

Last updated

2014-11-24

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Atelectasis

Brief summary

This study evaluates whether sustaining inspiratory pressure for 10 seconds at a time can open collapsed lung areas in non-dependant regions of the lung in mechanically ventilated patients.

Detailed description

Collapse of lung volume, atelectasis, is a common complication in sedated and mechanically ventilated patients. In adults the atelectasis occur mainly in the dependant areas of the lung. In this study the investigators examine whether these atelectasis can be opened by repeatedly sustaining the inspiratory pressure for 10 seconds when the patient has been positioned so that the atelectasis is located in a non-dependant position. Furthermore, the investigators examine how many times the inspiratory pressure needs to be sustained before the atelectasis is opened and at what pressure.

Interventions

OTHERInspiratory hold

Sustainment of the ventilators inspiratory pressure for 10 seconds at a time

Study design

Allocation

Intervention model

SINGLE_GROUP

Primary purpose

TREATMENT

Masking

NONE

Eligibility

Sex/Gender

ALL

Age

18 Years to No maximum

Healthy volunteers

Inclusion criteria

* Continuously or intermittently mechanically ventilated with artificial airway (endotracheal tube or tracheostomy tube) * Pressure controlled or pressure supported ventilator mode * PEEP ≤ 12 cm H2O, registered peak pressure ≤ 32 cm H2O * Non-ventilated lung regions according to E.I.T. measurements * Richmond Agitation Score 0 -(-5) * Circulatory stable or stabilized

Exclusion criteria

* Pregnancy * BMI \> 50 * Pacemaker or other electrically active implants * Skin lesions, wounds or bandages on chest area where E.I.T. belt needs to be placed * Undrained pneumothorax * Pulsating air-mattress * Unstable skeletal injury to spinal column * Recent brain injury or spinal chord injury * Recent injury to heart, to major blood vessels in chest, to major airways or to the oesophagus.

Design outcomes

Primary

Measure	Time frame	Description
Ventilation in previously non-ventilated lung tissue	During intervention and for 30 minutes after ended intervention	Registered using electrical impedance tomography, E.I.T., via PulmoVista500 by Dräger Medical

Countries

Norway

Contacts

Primary ContactSarah LB Wilberg, Bachelor

sara-wi@online.no+47 95 80 82 90

Backup ContactKnut Gaustad, MD

knut.gaustad@getmail.no+47 41 55 25 76

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026