Amphetamine Addiction
Conditions
Keywords
drug carving changes during rehabilitation, community, DNA
Brief summary
The purpose of this research is to inspire new medical ideas using brain image technology for the treatment of Amphetamine Type Stimulus addition, at the same time lowing the addition damage.
Detailed description
The study will increase the sample size based on the preliminary work,also, establish drug dependence induced craving associated environmental experiments , by using the multi-lead biofeedback instrument , CogState tester, event-related potentials Recorder and 3.0T high-field magnetic resonance imaging system to record the physiology , electrophysiology and brain changes during craving, taking a subjective self-assessment , clinical observations and physiological responses combined system to evaluate the ATS addiction degree.
Interventions
RADIATIONrTMS 10HZ high frequency stimulation
Stimulate the dorsolateral prefrontal and parietal lower part , 4 weeks of therapeutic intervention (5 times / week).
BEHAVIORALpsychological rehabilitation training
The main content is self-awareness training, social and moral strengthening, impulse control training , problem solving training , situational awareness training , HIV prevention, social skills training under the family atmosphere , family social skills training , interpersonal skills training, community interaction skills training , psychiatric symptoms of self-monitoring skills training and so on.
BEHAVIORALphysical and neurological rehabilitation training
The main content is drug rehabilitation exercise and functional physical training. Rehabilitation led by the discipline cadres , practice once a day, each lasting about 15 minutes .
RADIATIONfake rTMS 10HZ high frequency stimulation
Fake stimulate the dorsolateral prefrontal and parietal lower part , 4 weeks of therapeutic intervention (5 times / week).
Sponsors
Shanghai Mental Health Center
Study design
Allocation
RANDOMIZED
Intervention model
FACTORIAL
Primary purpose
PREVENTION
Masking
NONE
Eligibility
Sex/Gender
ALL
Age
18 Years to 49 Years
Healthy volunteers
No
Inclusion criteria
* No previous history of any mental disorder meet the DSM-IV diagnosis * aged 18-49 years old , men and women * junior high school or higher education * use of amphetamine-type substances time for more than one year * cumulative use of amphetamines, substances dose of 50 grams or more.
Exclusion criteria
* Current or past had suffered neurological diseases * exclusion of antisocial personality disorder and borderline personality disorder * addicts in addition to other substances in tobacco , coffee, social drinking outside * AIDS virus (HIV) detection positive patients .
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| the prevalence of ATS abuse or dependence characteristics and pathogenesis | Baseline | Plasma and DNA samples were collected to carry out the biochemical genetics and immunology research of ATS abuse or dependence , and to explore the prevalence of ATS abuse or dependence characteristics and pathogenesis. |
| the physiological psychology and cognitive impairment characteristic of ATS addicts,trends and ATS conducted cases. | Baseline | Use repeatable battery for the assessment of neuropsychological status(RBANS),Cog-state cognitive function assessment test,event-related potentials(ERPs),functional magnetic resonance imaging(fMRI) in biology ( molecular genetics, blood biochemistry, electrophysiology , imaging ) , psychology, mental health and other aspects of the system to assess the physiological psychology and cognitive impairment characteristic of ATS addicts , trends and ATS conducted cases. |
Countries
China
Outcome results
None listed