Precedex Effect to Propofol Requirement
Conditions
Brief summary
Propofol frequently used as an inducting medication for insertion Laryngeal mask airway(LMA). But propofol alone can be not sufficient for inhibiting upper airway reflex and also result in cardiovascular suppression under enough amount. Dexmedetomidine is a selective alplh2 receptor agonist with analgesic and sedative effects but sparing respiratory function. Therefore propofol combined with dexmedetomidine induction could be more effective in preserve respiration under same condition for LMA insertion than propofol alone. In this study, the investigators investigate the clinical dose of propofol for LMA insertion with premedication of dexmedetomidine, and evaluate the effect of dexmedetomidine.
Interventions
DRUGDexmedetomidine
DRUGNormal saline
Sponsors
Ajou University School of Medicine
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Masking
DOUBLE (Subject, Investigator)
Eligibility
Sex/Gender
ALL
Age
19 Years to 60 Years
Healthy volunteers
Yes
Inclusion criteria
* patients for surgery not exceed more than 2 hours requiring general anesthesia
Exclusion criteria
* history of gastroesophageal reflux High grade obesity Predicted diffiicult airway
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Fail or success for Laryngeal Mask Airway (LMA) insertion | During inserting LMA and up to 5 seconds after LMA inserion | Failure for LMA insertion is defined if there is a difficulty for mouth opening or active movement of four limbs or head. Success is smooth LMA insertion without any movement |
Countries
South Korea
Outcome results
None listed