Decreased Pulmonary Function, Insulin Resistance
Conditions
Keywords
Insulin resistance, Pulmonary function, Phthalates
Brief summary
* Phthalate is an endocrine disrupting chemical, which works as an anti-androgenic agent. * Phthalate is mainly used as PVC plasticizer and easily found in commonly used products such as electronic device, paint, lubricant, surfactant, medical supplies, spray etc. Especially, PVC blood bag used for blood transfusion have been reported to have high level of phthalate concentration. * Previous studies reported that urinary concentration of phthalate metabolites and HOMA (Homeostatic model assessment, indicator of insulin resistance) has positive association. * Previous studies also reported negative associations between urinary phthalate concentration and pulmonary function. * Exposure to phthalates occurs mainly through oral route. Food wrapping with phthalate containing package material is expected to be one of the major contributor for phthalate exposure. * In this present trial, the investigators are to examine whether increased phthalate exposure by consuming beverage stored in PVC containing packing materials actually effect insulin resistance, pulmonary function and epigenetic feature. * For this aim, the investigators will conduct a cross-over trial.
Interventions
OTHERnon- PVC containing packing materials
Beverage which was stored in glass bottle for 24 hours in 4 ℃.
OTHERPVC containing packing materials
Beverage which was stored in PVC blood bag for 24 hours in 4 ℃.
Sponsors
Seoul National University Hospital
Study design
Allocation
RANDOMIZED
Intervention model
CROSSOVER
Primary purpose
BASIC_SCIENCE
Masking
TRIPLE (Subject, Caregiver, Outcomes Assessor)
Eligibility
Sex/Gender
ALL
Age
60 Years to 85 Years
Healthy volunteers
Yes
Inclusion criteria
* Participants who understand aim of this study and who provided informed consent
Exclusion criteria
* Who did not provided informed consent * Person who are undergoing or planning to take a treatment due to liver, nervous system, respiratory system, hematologic, oncologic, psychiatric, cardiovascular(angina pectoris, myocardial infarction, stroke etc), endocrinal(Diabetes mellitus, thyroid disease) disorders.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Increase of insulin resistance assessed by HOMA (Homeostatic model assessment) | average 14 hours after consumption of assigned food and beverage |
Secondary
| Measure | Time frame |
|---|---|
| Decrease of lung function assessed by FEV1 | average 14 hours after consumption of assigned food and beverage |
| Decrease of lung function assessed by FVC | average 14 hours after consumption of assigned food and beverage |
| Change of DNA methylation assessed by Percent DNA methylation | average 14 hours after consumption of assigned food and beverage |
| Decrease of lung function assessed by FEF25-75 | average 14 hours after consumption of assigned food and beverage |
| Increased exposure to Phthalate assessed by urinary concentration of metabolites | average 14 hours after consumption of assigned food and beverage |
| Decrease of lung function assessed by FEV1/FVC | average 14 hours after consumption of assigned food and beverage |
Countries
South Korea
Contacts
Primary ContactSanghyuk Bae, MD, PhD
Outcome results
None listed