Dual Energy CT Urography With Reduced Iodinated Contrast

Dual Energy CT Urography Using 50% Reduction in Iodinated Contrast: Feasibility, Image Quality, and Radiation Dose Reduction With Virtual Unenhanced Images.

Status

Completed

Phases

Study type

Interventional

Source

ClinicalTrials.gov

Registry ID

NCT02283307

Enrollment

Registered

2014-11-05

Start date

2014-09-30

Completion date

2017-08-31

Last updated

2018-05-14

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Aortic Aneurysm

Brief summary

The goal of this study is to validate that Dual Energy CT (DECT) urography when performed with a 50% reduction in iodinated contrast dose results in a CT exam with equal or better image quality and equal or better diagnostic capability compared to traditional Single Energy CT (SECT) performed with a standard contrast dose.

Detailed description

The investigators hypothesize that DECT urography performed with a 50% iodine dose reduction is equivalent to SECT urography performed with a full iodine dose for: * Enhancement of the aorta, renal arteries, and renal veins * Enhancement of the renal cortex * Enhancement of the renal pelvis, ureters, and bladder * Subjective evaluation of image quality * Objective evaluation of image quality In addition, the investigators hypothesize that DECT virtual non-contrast images using material suppression from the same low iodine CT exam results in equivalent diagnostic information compared to SECT true non-contrast images obtained in the same patient during the same exam. If the true non-contrast images could be replaced by the virtual non-contrast images without loss of information, there is potential for DECT to both significantly lower radiation dose as well as significantly decreasing iodine dose. The investigators designed this research protocol to prospectively test these hypotheses in a population scanned with a 50% reduced iodine DECT urography protocol compared to a control population scanned with a standard iodine dose clinical SECT urography protocol.

Interventions

OTHERReduced contrast DECT scan

Subjects will undergo a dual energy CT scan with reduced contrast

OTHERStandard contrast SECT scan

Subjects will undergo standard of care single energy CT scan with a standard dose of contrast. (control)

Study design

Allocation

Intervention model

SINGLE_GROUP

Primary purpose

DIAGNOSTIC

Masking

NONE

Eligibility

Sex/Gender

ALL

Age

50 Years to No maximum

Healthy volunteers

Inclusion criteria

* Age \>50 * Outpatient scheduled to have a CT urography at the site

Exclusion criteria

* Severe allergy to iodine containing contrast * Pregnancy (which is very unlikely for those over 50) * Body mass index (BMI) over 35 kg/m2 * Inability to provide informed consent * Inpatient

Design outcomes

Primary

Measure	Time frame
Diagnostic ability determined by image quality (subjective and objective evaluation of vessel attenuation and depiction, image noise, image quality and information from virtual non-contrast	Up to 24 months

Countries

United States

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026