Critically Ill
Conditions
Keywords
leptin levels, ghrelin levels
Brief summary
Enteral alimentation is the preferred modality of support in critical patients who have acceptable digestive function and are unable to eat orally, but the advantages of continuous versus intermittent administration are surrounded by controversy. This prospective, randomised study was designed to compare two enteral feeding methods with respect to changes in levels of leptin and ghrelin in ICU.
Interventions
OTHERenteral feeding by nasogastric tube.
method of administration enteral feeding by nasogastric tube.
Sponsors
özgür yağan
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
DIAGNOSTIC
Masking
SINGLE (Investigator)
Eligibility
Sex/Gender
ALL
Age
18 Years to 85 Years
Healthy volunteers
No
Inclusion criteria
* who were unable to ingest an oral diet * given decision on enteral feeding
Exclusion criteria
* Carcinomatosis * irreversible coma * death or discharge before 14 days of observation * contraindication to enteral feeding * intolerance to the prescribed nutrients or infusion regimen * burn * multiple trauma * morbid obesity * end stage liver or renal or lung disease * severe sepsis or septic shock * patients with percutaneous endoscopic gastrostomy * immunosuppressive drug use * severe hemodynamic instability * massive blood transfusion
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Change from baseline in serum leptin concentration at three weeks in ICU | first, 7th, 14th and 21th day |
| Change from baseline in serum ghrelin concentration at three weeks in ICU | first, 7th, 14th and 21th day in ICU |
Countries
Turkey (Türkiye)
Outcome results
None listed