PEEP Influence on Gas Exchange During Early Weaning

The Influence of Different PEEP Values on Gas Exchange in Spontaneously Breathing Patients During Early Weaning

Status

Withdrawn

Phases

Study type

Interventional

Source

ClinicalTrials.gov

Registry ID

NCT02281695

Acronym

MHOPEEP

Enrollment

Registered

2014-11-03

Start date

2014-10-31

Completion date

2018-12-31

Last updated

2022-09-01

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Respiratory Failure

Brief summary

The purpose of this study is to determine the differences in oxygenation and decarboxylation between two weaning processes.

Detailed description

First, during controlled mechanical ventilation all patients will be ventilated for 5 minutes with 100% oxygen. After 5 minutes an PaO2/FiO2 will be calculated and compared with a PaO2/FiO2 during ventilation with FiO2 - 30%. The patients will be divided in two sections: Section A are the patients with less than 24 hours mechanical ventilation until weaning start. Section B are the patients with more than 24 hours until weaning start. The patients in every section will be further divided in two groups. Group 1 will be weaned starting with a PEEP equal with P mean during BiPAP, Group 2 will be weaned starting with a PEEP equal with PEEP during BiPAP. Further, the weaning will be conducted after an known algorithm. The differences in the oxygenation and decarboxylation will be measured after 30 and 120 Minutes for Group A and after 30, 120, 240, 360 Minutes for Group B.

Interventions

OTHERPEEP adjusment during the Weaning process

The PEEP will be adjusted after an previously established algorithm and the differences in the arterial blood oxygen partial pressure will be compared.

Study design

Allocation

RANDOMIZED

Intervention model

SINGLE_GROUP

Primary purpose

SUPPORTIVE_CARE

Masking

NONE

Eligibility

Sex/Gender

ALL

Age

18 Years to No maximum

Healthy volunteers

Inclusion criteria

* All Patients that are mechanical ventilated on the intensive care unit.

Exclusion criteria

* Patients under 18 years of age * Patients that where in an other study in the last 30 days * Patients that are enrolled in other studies * Pregnant woman * Nursing mothers * Existing severe Lung disease * Existing COPD Gold IV

Design outcomes

Primary

Measure	Time frame
Changes in the Oxygen Partial Pressure and CO2 Partial Pressure in the arterial blood gas analysis	30, 60, 90, 120, 360 Minutes

Countries

Germany

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026