Aging
Conditions
Brief summary
As we age we tend to lose muscle mass and strength. These losses contribute to the increased incidence of falls and fractures, metabolic diseases such as type 2 diabetes, loss of independence and reduced quality of life in the elderly. As the number of seniors increases worldwide, it is becoming more and more important to develop strategies to counteract this loss of muscle mass and strength, and promote healthy aging. Fortunately, relatively simple lifestyle modifications are the most potent defense strategies. Exercises such as weight lifting and high-intensity interval exercise (HIIT), which consists of short, repeated bouts of vigorous aerobic exercise interspersed with period of rest, are the most effective in promoting gains in muscle mass and strength. Additionally, components of foods like whey (a protein found in milk), creatine (found in meat), calcium and vitamin D have been shown to independently increase strength. In this study, we are looking to determine how much we can increase muscle strength in older men who are put on an 12 week exercise training program that combines weight lifting and HIIT, and who consume a daily supplement that contains whey protein, creatine, calcium and vitamin D.
Detailed description
Please see other documentation.
Interventions
DIETARY_SUPPLEMENTSupplement
supplement/placebo plus exercise training
Sponsors
McMaster University
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
PREVENTION
Masking
DOUBLE (Subject, Investigator)
Eligibility
Sex/Gender
MALE
Age
60 Years to No maximum
Healthy volunteers
Yes
Inclusion criteria
* Sedentary (no participation in a structured exercise training program in past 6 months) * BMI between 18.5-30.0 kg/m2 * Weight stable for past 6 months * Normal resting blood pressure, or stage I hypertension
Exclusion criteria
* Smoking * Use of simvastatin or atorvastatin * Use of non-steroidal anti-inflammatory drugs * Injuries that prevent safe-participation in an exercise training program * Prescription blood thinners * Diabetes or other metabolic disorders * Cardiac or gastro-intestinal problems * Infectious disease or cancer
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Muscle mass | 12 weeks | DXA, ultrasound |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Muscle protein synthesis | 12 weeks | The incorporation of a stable isotope (deuterium) into muscle tissue will allow for the determination of fractional synthetic rate, which is indicative of muscle protein synthesis. |
| Satellite cell number, density, type I/type II fibre specific satellite cells and myonuclear domain | 12 weeks | Histochemical methods will be used to determine how the supplement and training affect muscle growth and regenerative capacity, specifically the behaviour of satellite cells. |
| Glycemic control | 12 weeks | Oral glucose tolerance test |
| Cognitive function | 12 weeks | Questionnaires and simple computer-based identification, reaction time and memory tasks. |
Countries
Canada
Outcome results
None listed