Infected by Chikungunya Virus
Conditions
Brief summary
Chikungunya is a viral disease transmitted by mosquitoes whose clinical feature is the early joint damage. Approximately 8% of patients have chronic arthropathy resembling to the rheumatoid polyarthritis. The EchoCHIK study we propose is in the context of the epidemic in Martinique which began in January 2014. It should give a better understanding of arthritis and juxtaarticular of CHIK and look for signs that may allow ultrasound predict the evolution of chronic arthropathy of CHIK.
Interventions
OTHERSF36 (QQoL)
use of quality of life questionnaire (SF 36) ( at enrollment visit, at 3 month, at 6 month and at12 month for the following visits)
Sponsors
University Hospital Center of Martinique
Study design
Observational model
COHORT
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
45 Years to No maximum
Healthy volunteers
No
Inclusion criteria
1. Age at onset of symptoms ≥ 45 years 2. Seen in consultation at the University Hospital of Fort-de-France 3. Suspected chikungunya infection (fever and sudden onset of joint pain affecting the wrists, hands, ankles or knees) 4. Duration of symptoms suggestive of infection chikungunya less than or equal to 10 days 5. Presence of joint pain on the day of inclusion 6. No history of inflammatory arthritis 7. Absence of steroidal or non-steroidal anti-inflammatory drugs taken within two weeks prior to inclusion 8. Ability to participate in the study throughout its duration (12 months) 9. Patient affiliated or beneficiary of a social health care. 10. Acceptance to participate in the study and monitoring proposed and signed informed consent
Exclusion criteria
1. Age at onset of symptoms \<45 years 2. Duration of symptoms suggestive of chikungunya for more than 10 days 3. Lack of joint pain on the day of inclusion 4. History of inflammatory arthritis Nonsteroidal anti-inflammatory drugs or 5. Taking in the two weeks preceding the inclusion 6. Inability to participate in the study throughout its duration (12 months) 7. Patient is not affiliated or beneficiary of a social health care. 8. Refusal to participate in the study or to sign a consent
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Presence of sonographic signs observed during the initial scan: periarticular infiltration, effusion, positive Doppler, erosions. | enrollement visit | Progression to chronic form defined by the persistence or recurrence of muscle symptoms (myalgia) and joints (arthralgia, arthritis) more than two months after the onset of symptoms of acute phase. |
Secondary
| Measure | Time frame |
|---|---|
| Presence of clinical and sonographic signs observed at each visit: arthralgia, arthritis clinics, periarticular infiltration, effusion, positive Doppler erosions. | 1 month, 3 month, 6 month and 12 month after the first symptoms of infection by chikungunya virus |
Countries
Martinique
Outcome results
None listed