Acute Coronary Syndrome
Conditions
Keywords
titanium-nitride-oxide-coated stent, everolimus-eluting stent, optical coherence tomography, strut coverage
Brief summary
The purpose of this study is to compare vascular healing of the stented segment after deployment of titanium-nitride-oxide coated cobalt-chromium Optimax™-stent stent and Promus-Element™ everolimus-eluting stent in patients with acute coronary syndromes requiring percutaneous coronary intervention. 1. Comparison of OCT and CFR findings of titanium-nitride-oxide coated cobalt-chromium Optimax™-stent and Promus-Element™ everolimus-eluting stent at two months after the index procedure. 2. Comparison of intravascular coronary flow reserve measurement to non-invasive transthoracic echocardiography-derived coronary flow reserve measurement. 3. Comparison of epicardial vasodilation to coronary microcirculatory vasodilation
Interventions
PROCEDUREStenting using Optimax™
PROCEDUREStenting using PROMUS Element™ Plus
Sponsors
The Hospital District of Satakunta
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT
Masking
NONE
Eligibility
Sex/Gender
ALL
Age
18 Years to 80 Years
Healthy volunteers
No
Inclusion criteria
1. Age \>18 and \<80 years 2. STEMI or NSTEMI (assumed by investigator to be type 1 myocardial infarction, according to universal definitions of MI; EHJ 2007; 28(20):2525-38); or unstable angina (clinical symptoms of chest pain, ecg suggestive of reversible ischemia) 3. Patient is willing to comply with specified follow-up evaluations 4. Patient or legally authorized representative has been informed of the nature of the study, agrees to its provisions and has been provided written informed consent, approved by the appropriate Medical Ethics committee or Institutional Review Board 5. Single de novo or non-stented restenosis lesion 6. Patients with two-vessel disease may have undergone successful treatment of the non-target vessel with approved devices up to and including the index procedure but must be prior to the index target vessel treatment 7. Target lesion (maximum 20 mm length by visual estimation) to be covered by a single stent of maximum 23mm length 8. Reference vessel diameter must be \>2.5mm and \<4.0mm by visual estimate. 9. The vessel diameter should be measured after pre-dilation procedure and after intracoronary nitroglycerin if vasospasm is suspected 10. Target lesion \>50% and \<100% stenosed by visual estimate
Exclusion criteria
1. Pre-existing diagnosis of diabetes irrespective of its type 2. Impaired renal function (serum creatinine \>177micromol/l) or on dialysis 3. Platelet count \< 10 e5 cells/mm3 4. Patient has a history of bleeding diathesis or coagulopathy or patients in whom antiplatelet and and/or anticoagulation therapy is contraindicated 5. Patient has received organ transplant or is on a waiting list for any organ transplant 6. Patient has a known hypersensitivity or contraindication to aspirin, heparin/bivalirudin, clopidogrel/prasugrel, stainless steel alloy, or contrast agent that cannot be adequately pre-medicated 7. Patient presents with cardiogenic shock 8. Any significant medical condition which in the Investigator's opinion may interfere with the patient's optimal participation in the study 9. Currently participating in another intestigational drug or device study 10. Unprotected left main disease 11. Ostial target lesions 12. Chronic total occlusion 13. Calcified target lesions that cannot be adequately pre-dilated 14. Target lesion has excessive tortuosity unsuitable for stent delivery and deployment 15. Target lesion involving bifurcation with a side branch larger than 2.0mm in diameter 16. A \>30% stenosis proximal or distal to the target lesion that cannot be covered with the same stent 17. Diffuse distal disease 18. Prior stent in the target vessel
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Percentage of uncovered struts | 2 months |
Secondary
| Measure | Time frame |
|---|---|
| Coronary flow reserve | 2 months |
Countries
Finland
Outcome results
None listed