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Iodine Status of Preschoolers Given Micronutrient Powder for 6 Months

Iodine Intake & Status of Preschoolers Given Micronutrient Powder for 6 Months

Status
Completed
Phases
Phase 4
Study type
Interventional
Source
ClinicalTrials.gov
Registry ID
NCT02280330
Acronym
MNP-CAR
Enrollment
396
Registered
2014-10-31
Start date
2014-11-30
Completion date
2015-03-31
Last updated
2015-12-23

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Hypothyroidism, Iodine Deficiency, Iodine Deficiency Disorder

Keywords

Iodine Deficiency, Micronutrient Powder, Hypothyroidism

Brief summary

Iodine deficiency remains widespread worldwide with children as among the vulnerable groups considering their stage of growth and development. In the Philippines, current data shows an optimal status among schoolchildren, however no data exists on iodine status nor intake of preschool children. One recent approach to improvement of the vitamin and mineral status of the population is home fortification using micronutrient powder or MNP. This contains 15 vitamins and minerals, including iodine and iron. Current guidelines exist for MNP use to improve iron status and reduce anemia among infants and young children 6-23 months old, but did not mention use among preschoolers such as those in day care centers. This study, therefore, aims to compare the iodine status and growth of day care children given MNP for 6 months.

Detailed description

Iodine is an essential trace element for normal growth and development in animals and man (Hetzel, 1989). When iodine requirements are not met, thyroid hormone synthesis is impaired resulting in hypothyroidism and a series of functional and development abnormalities called iodine deficiency disorders or IDD develop (WHO, 2007). WHO estimated that two billion people worldwide, including 1/3 of school-age children (de Benoist et al. cited by Zimmerman, 2011) suffer from iodine deficiency. Evidence is lacking as to whether schoolchildren are good proxy for other groups such as young children (Sullivam, 2010). In the Philippines, no data exists on the iodine status of preschool children. One recent approach for improving the vitamin and mineral status of the population is the use of micronutrient powder which contains 15 vitamins and minerals including iodine (HF-TAG 2011). While the MNP has been found effective to improve iron status, its effectiveness in improving iodine status has yet to be studied. Further, the provision of iodine through MNPs as well as the combined impact of salt iodization and use of MNPs, warrant investigation. It would also be of interest to generate data on the knowledge, attitude and practices of their parents or other caregiver who primarily take care of planning and provision of food for the family on iodine, iodized salt and MNP. Day care centers (DCC) are chosen as the site of the study considering their conduct of 120-days supplementary feeding yearly and the organized structure presents a better compliance and easier monitoring of use. Further, the day care pupils, more or less, represent the preschoolers in the barangay and there may be commonality (homogeneity) of the children in age and other characteristics. In the absence of guidelines for MNP use among children 24 months or older, the existing guidelines such as 60 sachets in 6 months as stipulated in DOH AO 2011-0303 will be followed.

Interventions

DIETARY_SUPPLEMENTMNP group

MNP contains 15 vitamins an minerals, including Vitamin ADEC, B1, B2, B6, B12, Niacin, Folic Acid, Iron, Zine, Copper, Selenium and Iodine. There is 90 microgram of iodine per sachet of one gram of MNP.

OTHERPlacebo group

The placebo is maltodextrin which is prepared as a white powder with similar physical characteristics and taste as MNP.

Sponsors

Nutrition Center of the Philippines
Lead SponsorOTHER

Study design

Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
SUPPORTIVE_CARE
Masking
TRIPLE (Subject, Caregiver, Investigator)

Eligibility

Sex/Gender
ALL
Age
4 Years to 6 Years
Healthy volunteers
Yes

Inclusion criteria

* apparently healthy * permanent resident in the barangay or municipality * 4-6 years old * with informed written parental consent * whose mothers are willing to devote time for the survey

Exclusion criteria

* severely underweight * with obvious clinical problem like goiter, congenital heart disease * with plans of transferring residence outside the municipality within the next 6 months

Design outcomes

Primary

MeasureTime frame
Iodine status based on urinary iodine measures6 months

Secondary

MeasureTime frameDescription
Levels of iodine intake6 months
Association of child characteristics with iodine intake6 monthsChild characteristics include age, birth order, common illnesses
Association of mother/caregiver characteristics with iodine intake6 monthsMother / Caregiver information includes age, religion, ethnic tribe, educational attainment, occupation and economic role in the family
Change in growth as indicated by anthropometric parameters such as weight for age and height for age6 months
Association of environmental sanitation with iodine intake6 monthsEnvironmental sanitation includes garbage disposal, drinking water, house premise, handwashing
Likability of a communication material on the knowledge of the mothers/caregivers regarding iodine, iodized salt and micronutrient powder6 monthsIncluded here is a survey on preference of communication material, preferred size, color and topic for Iodine, Iodized salt and micronutrient powder
Association of household characteristics with iodine intake6 monthsHousehold information includes status of residence, length of residence, type of residence, nature of living arrangement, source of drinking water, household number, main source of income and estimated family income

Countries

Philippines

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026