Coronary Artery Disease
Conditions
Brief summary
The study will assess coronary flow reserve by PET-H215O and FFR in patients suspected of coroanry artery disease. This a comparative study with dynamic acquisition using CZT camera and 99mcTc-mibi. 20 patients will have those measurements.
Interventions
OTHERASSESSMENT OF CORONARY FLOW RESERVE BY PET-H215O AND FFR
Sponsors
Spectrum Dynamics
University Hospital, Caen
Study design
Allocation
NA
Intervention model
SINGLE_GROUP
Primary purpose
DIAGNOSTIC
Masking
NONE
Eligibility
Sex/Gender
ALL
Age
18 Years to 80 Years
Healthy volunteers
No
Inclusion criteria
* Patient between 18 and 80 years * Suspected coronary disease and / or coronary syndrome patient ST- * Patient who has been informed of the study and has given his informed consent * Patient affiliated to a social security system.
Exclusion criteria
* Patient having no coronary disease at coronary angiography with FFR on the 3 main epicardial arteries (absence of ≥ 50% stenosis of at least one artery) * Delay of Care grater than 30 days between the PET and SPECT imaging and the diagnostic coronary angiography * Patient with a recent history of myocardial infarction and STEMI, unstable angina * Patient with extra-cardiac disease whose prognosis can interfere with the treatment decision * Pregnant or lactating women * Patient allergic to contrast products during coronary angiography * Patient with MDRD clearance les than 60 ml / min * Patient Under guardianship, or unable to understand the purpose of the study
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Assess myocardial coronary reserve by cardiac CZT camera and Tcmibi comparing with the PET and the water marked during coronary FFR (Flow Fraction Reserve) | baseline |
Countries
France
Outcome results
None listed