Kidney Failure, Chronic
Conditions
Keywords
end-stage kidney disease, peritoneal dialysis, home hemodialysis, technique survival, patient survival
Brief summary
The purpose of this study is to evaluate which home dialysis modality pattern (home hemodialysis \[HHD\], peritoneal dialysis \[PD\] or a combination of both, e.g. PD and then HHD) allows for the longest home dialysis survival, as defined by the time dialysed in a home environment. The investigators hypothesize that patients transferred from one home modality to another will have a longer home dialysis survival compared to patients treated only with PD or HHD.
Interventions
PROCEDUREPeritoneal dialysis
PROCEDUREHome hemodialysis
Sponsors
Baxter Healthcare Corporation
Princess Alexandra Hospital, Brisbane, Australia
Study design
Observational model
COHORT
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
No
Inclusion criteria
* Patients with PD/HHD 90 days after RRT initiation between January 1, 2000 and December 31, 2012 reported in ANZDATA * ≥ 18 years
Exclusion criteria
* Less than 90 days of dialysis * \< 18 years * Patients transferred to Australia/New Zealand after initiation of dialysis in another country
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Home dialysis survival | Survival analysis; specific analysis at 5 years after dialysis initiation | Time to first patient death or home dialysis technique failure for each home dialysis modalities, censored for transplantation and loss to follow-up |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Patient survival, censored for technique failure | Survival analysis, specific analysis at 1,2 5 years after dialysis initiation | Patient survival on each specific home dialysis modality, censored for technique failure, transplantation and loss to follow-up |
| Home technique survival, censored for death | survival analysis, specific analysis at 1,2 5 years after dialysis initiation | Home dialysis technique survival for each home dialysis modality, censored for patient death, transplantation and loss to follow-up |
Other
| Measure | Time frame | Description |
|---|---|---|
| Home dialysis survival, case-control analysis | survival analysis, specific analysis at 1,2 5 years after dialysis initiation | Case-control analysis will be performed in order to address immortal bias in patients classified in the switchingcategories (PD-HHD or HHD-PD). Since we expect the HHD-PD group to be small, this analysis will be performed only with the 3 other groups (PD-HHD, PD only and HHD only). Patients treated successively with PD and HHD (cases) will be matched (by age and diabetes status) to patient treated with PD only and HHD only (controls). |
Outcome results
None listed