Biological Markers for the Diagnosis of Central Nervous System Infective Diseases

Diagnosis Value of Procalcitonin, Interleukin-6, AgiotensininⅡin the Cerebrospinal Fluid of Patients With Central Nervous System Infective Diseases

Status

UNKNOWN

Phases

Unknown

Study type

Observational

Source

ClinicalTrials.gov

Registry ID

NCT02278016

Enrollment

150

Registered

2014-10-29

Start date

2014-08-31

Completion date

2017-07-31

Last updated

2016-01-01

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Infection

Keywords

procalcitonin, interleukin-6, agiotensininⅡ

Brief summary

Bacterial meningitis is a potentially life-threatening disease that is associated with substantial neurological morbidity and mortality. Accurate diagnosis is essential to improve outcome and prevent antibiotic overuse. Here we try to explore new biological markers for the diagnosis of the central nervous system infection disease.

Detailed description

To investigate the diagnosis value of procalcitonin,interleukin-6, agiotensininⅡin the cerebrospinal fluid in the central nervous system infection disease.

Interventions

None listed

Study design

Observational model

CASE_ONLY

Time perspective

PROSPECTIVE

Eligibility

Sex/Gender

ALL

Age

13 Years to No maximum

Healthy volunteers

Yes

Inclusion criteria

1. Aged 13 years or older; 2. At least two of the following clinical characteristics:headache, fever, neck stiffness, mental symptoms or consciousness impairment or seizures 3. Patients' family signed informed consent.

Exclusion criteria

1. Contraindications to lumbar puncture 2. Patients with active malignancy

Design outcomes

Primary

Measure	Time frame	Description
Levels of procalcitonin, interleukin-6, agiotensininⅡ in the serum and cerebrospinal fluid	36 months	meet the clinical diagnostic criteria for the central nervous system infection disease, the blood and cerebrospinal fluid samples after onset.

Countries

China

Contacts

Primary Contactjiang wen, MD

jiangwen@fmmu.edu.cn029-84771319

Outcome results