Infertility
Conditions
Brief summary
The aim of the present study is to determine the effect of follicular flushing on the ongoing pregnancy rate in patients who developed four or fewer follicles of 14mm following standard ovarian stimulation for IVF.
Detailed description
Oocyte aspiration under the guidance of transvaginal ultrasound is an integral part in IVF treatment. Follicular flushing has been advocated. However, subsequent data from randomized trials failed to demonstrate any benefits with routine follicular flushing in normally responding patients. Instead, it has been shown to prolong the operating time, increase the procedure-related pain and analgesics requirement. Most of the IVF centers no longer perform routine follicular flushing in normally responding patients. The potential role of follicular flushing in patients with a limited number of developing follicles is conflicting based on the recently published randomized trials. The aim of the present study is to determine the effect of follicular flushing on the ongoing pregnancy rate in patients who developed four or fewer follicles of 14mm following standard ovarian stimulation for IVF.
Interventions
OTHERFlushing
aspiration of follicles that are larger than 10 mm on both sides followed by follicular flushing for up to 4 times. Follicular fluid and flushing will be examined by the embryologists to identify any oocytes.
Sponsors
The University of Hong Kong
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT
Masking
SINGLE (Subject)
Eligibility
Sex/Gender
FEMALE
Age
No minimum to 42 Years
Healthy volunteers
No
Inclusion criteria
1. Age of women \<43 years 2. Normal uterine cavity on saline sonogram 3. Endometrial thickness \>=8mm on the day of hCG
Exclusion criteria
1. Planned not to have fresh embryo transfer 2. Cycle cancelled prior to hCG administration 3. Natural cycle IVF 4. Presence of hydrosalpinges on scanning which are not surgically treated 5. Presence of endometrial polyps on scanning 6. Undergoing preimplantation genetic diagnosis
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| ongoing pregnancy rate | 10 weeks of gestation |
Secondary
| Measure | Time frame |
|---|---|
| number of oocytes retrieved | on the day of retrieval |
| number of embryo available for transfer | on the day of embryo transfer |
| clinical pregnancy rate | 6 weeks of gestation |
| operation time of the retrieval | on the day of retrieval |
| pain score of retrieval | on the day of retrieval |
Countries
China
Outcome results
None listed